ArticleBMC cancer2009
Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer.Bioscience reports · 2020Pooled it
- Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis.Oncotarget · 2017Pooled it
- FGFR2 and NOTCH1 Expression Inversely Correlated in Progressive Cutaneous Carcinogenesis in an Experimental Mouse Model.Journal of personalized medicine · 2024Article
- Association of the rs1966265 and rs351855Biomedicines · 2024Article
- Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer.Scientific reports · 2021Article
- Low-penetrance susceptibility variants and postmenopausal oestrogen receptor positive breast cancer.Journal of genetics · 2020Article
- Review
- Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection Pressure.International journal of molecular sciences · 2019Article
- Determination ofDisease markers · 2019Article
- Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer.Oncogene · 2017Article
- Contribution of glutathione S-transferase gene polymorphisms to development of skin cancer.International journal of clinical and experimental medicine · 2015Article
- Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?Current pharmaceutical design · 2014Review
- siRNA-participated chemotherapy: an efficient and specific therapeutic against gastric cancer.Journal of cancer research and clinical oncology · 2013Article
- FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer.PloS one · 2013Article
- Prognostic parameters for the primary care of melanoma patients: what is really risky in melanoma?Journal of skin cancer · 2011Article
- Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers.
methodsWe evaluated the associations of four genetic variants in the FGFR2 gene highly related to breast cancer risk and the three common tag-SNPs in the FGFR4 gene with skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.
resultsWe found no evidence for associations between these seven genetic variants and the risks of melanoma and nonmelanocytic skin cancer.
conclusionGiven the power of this study, we did not detect any contribution of genetic variants in the FGFR2 or FGFR4 genes to inherited predisposition to skin cancer among Caucasian women.
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