ArticleRadiation and environmental biophysics2009
A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation.
Article in Radiation and environmental biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship.International journal of radiation oncology, biology, physics · 2013Pooled it
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- Out-of-Field Dose Measurement by TLD Dosimetry and Estimation of Radiation-Induced Secondary Cancer Risk of Thyroid and Breast from Head Radiotherapy.Journal of biomedical physics & engineering · 2023Article
- Complete patient exposure during paediatric brain cancer treatment for photon and proton therapy techniques including imaging procedures.Frontiers in oncology · 2023Article
- Estimating cancer risks due to whole lungs low dose radiotherapy with different techniques for treating COVID-19 pneumonia.Radiation oncology (London, England) · 2022Article
- A software tool for organ-specific second cancer risk assessment from exposure to therapeutic doses.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Secondary cancer risk from modern external-beam radiotherapy of prostate cancer patients: Impact of fractionation and dose distribution.Journal of radiation research · 2021Article
- Risk of radiation-induced second malignant neoplasms from photon and proton radiotherapy in paediatric abdominal neuroblastoma.Physics and imaging in radiation oncology · 2021Article
- Low dose radiation therapy for COVID-19: Effective dose and estimation of cancer risk.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- Estimation of secondary cancer risk after radiotherapy in high-risk prostate cancer patients with pelvic irradiation.Journal of applied clinical medical physics · 2020Article
- Radiation-induced malignancies after intensity-modulated versus conventional mediastinal radiotherapy in a small animal model.Scientific reports · 2019Article
- A Comparative Evaluation of Normal Tissue Doses for Patients Receiving Radiation Therapy for Hodgkin Lymphoma on the Childhood Cancer Survivor Study and Recent Children's Oncology Group Trials.International journal of radiation oncology, biology, physics · 2016Article
- Risk-optimized proton therapy to minimize radiogenic second cancers.Physics in medicine and biology · 2015Article
- Visualization of risk of radiogenic second cancer in the organs and tissues of the human body.Radiation oncology (London, England) · 2015Article
- Modeling age-dependent radiation-induced second cancer risks and estimation of mutation rate: an evolutionary approach.Radiation and environmental biophysics · 2015Article
- Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses.Medical physics · 2015Article
- Minimizing second cancer risk following radiotherapy: current perspectives.Cancer management and research · 2015Review
- A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2014Article
- Abnormal tissue proliferation and life span variability in chronically irradiated dogs.Radiation and environmental biophysics · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
As the number of cancer survivors grows, prediction of radiotherapy-induced second cancer risks becomes increasingly important. Because the latency period for solid tumors is long, the risks of recently introduced radiotherapy protocols are not yet directly measurable. In the accompanying article, we presented a new biologically based mathematical model, which, in principle, can estimate second cancer risks for any protocol. The novelty of the model is that it integrates, into a single formalism, mechanistic analyses of pre-malignant cell dynamics on two different time scales: short-term during radiotherapy and recovery; long-term during the entire life span. Here, we apply the model to nine solid cancer types (stomach, lung, colon, rectal, pancreatic, bladder, breast, central nervous system, and thyroid) using data on radiotherapy-induced second malignancies, on Japanese atomic bomb survivors, and on background US cancer incidence. Potentially, the model can be incorporated into radiotherapy treatment planning algorithms, adding second cancer risk as an optimization criterion.
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