ArticleActa pharmacologica Sinica2009
Nonlinear dynamical analysis of carbachol induced hippocampal oscillations in mice.
Article in Acta pharmacologica Sinica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of AβAging and disease · 2025Article
- Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting.Pharmacological reviews · 2024Review
- Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations.Acta neuropathologica communications · 2023Article
- Astrocytes contribute to gamma oscillations and recognition memory.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.CNS neuroscience & therapeutics · 2013Article
- Amyloid Beta-Protein and Neural Network Dysfunction.Journal of neurodegenerative diseases · 2013Review
- Amyloid Beta peptides differentially affect hippocampal theta rhythms in vitro.International journal of peptides · 2013Article
- Amyloid Beta Peptide slows down sensory-induced hippocampal oscillations.International journal of peptides · 2012Article
- Complexity of VTA DA neural activities in response to PFC transection in nicotine treated rats.Journal of neuroengineering and rehabilitation · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimHippocampal neuronal network and synaptic impairment underlie learning and memory deficit in Alzheimer's disease (AD) patients and animal models. In this paper, we analyzed the dynamics and complexity of hippocampal neuronal network synchronization induced by acute exposure to carbachol, a nicotinic and muscarinic receptor co-agonist, using the nonlinear dynamical model based on the Lempel-Ziv estimator. We compared the dynamics of hippocampal oscillations between wild-type (WT) and triple-transgenic (3xTg) mice, as an AD animal model. We also compared these dynamic alterations between different age groups (5 and 10 months). We hypothesize that there is an impairment of complexity of CCh-induced hippocampal oscillations in 3xTg AD mice compared to WT mice, and that this impairment is age-dependent.
methodsTo test this hypothesis, we used electrophysiological recordings (field potential) in hippocampal slices.
resultsAcute exposure to 100 micromol/L CCh induced field potential oscillations in hippocampal CA1 region, which exhibited three distinct patterns: (1) continuous neural firing, (2) repeated burst neural firing and (3) the mixed (continuous and burst) pattern in both WT and 3xTg AD mice. Based on Lempel-Ziv estimator, pattern (2) was significantly lower than patterns (1) and (3) in 3xTg AD mice compared to WT mice (P<0.001), and also in 10-month old WT mice compared to those in 5-month old WT mice (P<0.01).
conclusionThese results suggest that the burst pattern (theta oscillation) of hippocampal network is selectively impaired in 3xTg AD mouse model, which may reflect a learning and memory deficit in the AD patients.
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