Evidence map›Paper›PMID 19498380›Full record

ReviewNature reviews. Immunology2009

MHC class I antigen presentation: learning from viral evasion strategies.

Ted H Hansen, Marlene Bouvier

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed.

  1. Review
  2. Review
  3. The diverse functions of viral microproteins.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Optimization of CEST MRI Reporter Protein Design Using Cation-Pi Networks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Polio virotherapy provokes MDA5 signaling and CD4Microbiology and molecular biology reviews : MMBR · 2025
    Review
  18. Article
  19. Article
  20. Article

189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ted H HansenWashington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA.
Marlene Bouvier

Funding

MHC-I regulation by herpes virusR01AI019687 · NIAID · WASHINGTON UNIVERSITY · PI FREMONT, DAVED H. · 1985 to 2016
$5.2M
IN VITRO FOLDING AND ASSEMBLY OF CLASS I MHC MOLECULESR01AI045070 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOUVIER, MARLENE · 2000 to 2011
$2.5M
In vitro folding and assembly of class I MHC moleculesR56AI045070 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI BOUVIER, MARLENE · 2006 to 2006
$325k
NIAID NIH HHS AI019687NIAID NIH HHS AI045070NIAID NIH HHS R01 AI045070
6 · The paper itself

Abstract

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides. This Review highlights how the elucidation of mechanisms of viral immune evasion is important for advancing our understanding of virus-host interactions and can further our knowledge of the MHC class I presentation pathway as well as other cellular pathways.

Indexed as

Antigen PresentationAnimalsATP-Binding Cassette TransportersB-LymphocytesEnzyme InhibitorsHistocompatibility Antigens Class IHumansMembrane Transport ProteinsProteasome Endopeptidase ComplexT-LymphocytesUbiquitinUbiquitin-Protein LigasesViral ProteinsVirusesATP-Binding Cassette TransportersEnzyme InhibitorsHistocompatibility Antigens Class IMembrane Transport ProteinsProteasome Endopeptidase ComplextapasinUbiquitinUbiquitin-Protein LigasesViral Proteins

Identifiers

PMID19498380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.