Trial reportObesity (Silver Spring, Md.)2009
Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents.
Trial report in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression.BMJ open · 2019Pooled it
- Weight loss in MASLD restores the balance of liver fatty acid sources.The Journal of clinical investigation · 2025Trial
- Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study.Pediatric obesity · 2025Trial
- Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion.The Journal of clinical endocrinology and metabolism · 2017Trial
- Threshold for improvement in insulin sensitivity with adolescent weight loss.The Journal of pediatrics · 2013Trial
- Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients.Diabetes care · 2012Trial
- Vertical Sleeve Gastrectomy Versus Comprehensive Lifestyle Intervention for Adolescents With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Controlled Cohort Study.Alimentary pharmacology & therapeutics · 2026Article
- Case Report: Dramatic metabolic improvement with tirzepatide in a patient with acquired partial lipodystrophy following hematopoietic stem cell transplantation.Frontiers in endocrinology · 2026Article
- E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet.International journal of molecular sciences · 2022Article
- The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis-Dysregulation by the Liver.Journal of clinical medicine · 2021Review
- What Change in Body Mass Index Is Required to Improve Cardiovascular Outcomes in Childhood and Adolescent Obesity through Lifestyle Interventions: A Meta-Regression.Childhood obesity (Print) · 2020Article
- PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements.Nutrition & diabetes · 2019Article
- Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers.Metabolism open · 2019Article
- Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology.The Journal of nutritional biochemistry · 2018Article
- Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function.Physiological reports · 2017Article
- Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program.Medicine · 2017Observational
- Reduced sCD36 following weight loss corresponds to improved insulin sensitivity, dyslipidemia and liver fat in obese children.European journal of clinical nutrition · 2016Article
- Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats.Medicine and science in sports and exercise · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Obesity in adolescents is associated with metabolic risk factors for type 2 diabetes, particularly insulin resistance and excessive accumulation of intrahepatic triglyceride (IHTG). The purpose of this study was to evaluate the effect of moderate weight loss on IHTG content and insulin sensitivity in obese adolescents who had normal oral glucose tolerance. Insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp technique in conjunction with stable isotopically labeled tracer infusion, and IHTG content, assessed by using magnetic resonance spectroscopy, were evaluated in eight obese adolescents (BMI >or=95th percentile for age and sex; age 15.3 +/- 0.6 years) before and after moderate diet-induced weight loss (8.2 +/- 2.0% of initial body weight). Weight loss caused a 61.6 +/- 8.5% decrease in IHTG content (P = 0.01), and improved both hepatic (56 +/- 18% increase in hepatic insulin sensitivity index, P = 0.01) and skeletal muscle (97 +/- 45% increase in insulin-mediated glucose disposal, P = 0.01) insulin sensitivity. Moderate diet-induced weight loss decreases IHTG content and improves insulin sensitivity in the liver and skeletal muscle in obese adolescents who have normal glucose tolerance. These results support the benefits of weight loss therapy in obese adolescents who do not have evidence of obesity-related metabolic complications during a standard medical evaluation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.