Trial reportObesity (Silver Spring, Md.)2009
Reversal of small, dense LDL subclass phenotype by normalization of adiposity.
Trial report in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial.Cardiovascular diabetology · 2019Trial
- Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2013Trial
- Reversal of small, dense LDL subclass phenotype by weight loss is associated with impaired fat oxidation.Obesity (Silver Spring, Md.) · 2011Trial
- Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes.Cardiovascular diabetology · 2020Article
- Influence on Adiposity and Atherogenic Lipaemia of Fatty Meals and Snacks in Daily Life.Journal of lipids · 2017Review
- The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss.EXCLI journal · 2016Article
- Fructose content of low calorie diets: effect on cardiometabolic risk factors in obese women with polycystic ovarian syndrome: a randomized controlled trial.Endocrine connections · 2015Article
- Multi-omic signature of body weight change: results from a population-based cohort study.BMC medicine · 2015Article
- Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and Treatment.Annual review of nutrition · 2015Review
- A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.Nutrition & metabolism · 2015Article
- Low-density lipoprotein cholesterol versus particle number in middle school children.The Journal of pediatrics · 2013Article
- Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches.Nutrients · 2013Review
- Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia.Journal of lipid research · 2012Article
- Dyslipidemia and pediatric obesity.Pediatric clinics of North America · 2011Review
- Energy substrate partitioning and efficiency in individuals with atherogenic lipoprotein phenotype.Obesity (Silver Spring, Md.) · 2011Article
- Article
- Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions.Journal of clinical lipidologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Excess adiposity and high-carbohydrate diets have been associated with an atherogenic lipoprotein phenotype (ALP) characterized by increased concentrations of small, dense low-density lipoprotein (LDL) particles (pattern B). We tested whether weight loss and normalization of adiposity could reverse ALP in overweight men with pattern B. After consuming a moderate-carbohydrate, high-fat diet for 3 weeks, pattern B and nonpattern B (pattern A) men were randomized to a weight loss (n = 60 and n = 36, respectively) or control weight-stable arm (n = 20 and n = 17, respectively). Men in the weight loss arm consumed approximately 1,000 fewer calories per day over 9 weeks to induce an average approximately 9 kg weight loss. In the control group, weight stability was maintained for 4 weeks after randomization. Weight loss led to the conversion of pattern B to pattern A in 58% of baseline pattern B men. Among men who achieved BMIs of <25 kg/m(2) (62% of pattern B men vs. 83% of pattern A men), 81% of pattern B men converted to pattern A. Weight loss was associated with a significantly greater decrease in small, dense LDL subclass 3b in pattern B relative to pattern A men. The lipoprotein profiles of pattern A men who converted from pattern B were comparable to those of men with pattern A at baseline. Conversion of LDL subclass pattern B to pattern A and reversal of ALP can be achieved in a high proportion of overweight men by normalization of adiposity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.