SynthesisThe American journal of emergency medicine2009
A systematic review of cardiovascular effects after atypical antipsychotic medication overdose.
Synthesis in The American journal of emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- A Case of Angiotensin II Utilization for Refractory Shock in a Polysubstance Overdose.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025Article
- Management of high-dose olanzapine poisoning in a young child under limited resource setting: a case report from Nepal.Annals of medicine and surgery (2012) · 2024Article
- Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation-Structured Literature Review and Analysis.Journal of xenobiotics · 2024Review
- Drugs Associated with Adverse Effects in Vulnerable Groups of Patients.Clinics and practice · 2024Review
- Second Generation Antipsychotics and Cardiovascular Adverse Effects: Developing Evidence-Based Recommendations for Primary Care Medicine.HCA healthcare journal of medicine · 2024Article
- A nomogram proposal for early prediction of intensive care unit admission in patients with acute antipsychotic poisoning.Toxicology research · 2023Article
- Abilifright: A Case Report of Massive Aripiprazole Overdose in a Toddler.Clinical practice and cases in emergency medicine · 2022Article
- Intensity of care delivered by prehospital emergency medical service physicians to patients with deliberate self-poisoning: results from a 2-day cross-sectional study in France.Internal and emergency medicine · 2019Article
- Intentional Recreational Abuse of Quetiapine Compared to Other Second-generation Antipsychotics.The western journal of emergency medicine · 2017Article
- Coma After Quetiapine Fumarate Intentional Overdose in a 71-year-old Man: A Case Report.Drug safety - case reports · 2015Article
- Emergency Department Visits Involving Misuse and Abuse of the Antipsychotic Quetiapine: Results from the Drug Abuse Warning Network (DAWN).Substance abuse : research and treatment · 2015Article
- Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data.European journal of pediatrics · 2014Article
- Evidence review and clinical guidance for the use of ziprasidone in Canada.Annals of general psychiatry · 2013Article
- Issues in the management of acute agitation: how much current guidelines consider safety?Frontiers in psychiatry · 2013Article
- Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner.Clinical pediatric emergency medicine · 2012Article
- Overdose of atypical antipsychotics: clinical presentation, mechanisms of toxicity and management.CNS drugs · 2012Review
- Quetiapine Sustained Release in Treatment of Delirium Induced by Cerebral Metastasis.Case reports in oncology · 2010Article
- Sustained hypotension with initial low dose of quetiapine in a middle-aged man receiving an antihypertensive agent.Primary care companion to the Journal of clinical psychiatry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
As the use of atypical antipsychotic medications (AAPMs) increases, the number of overdoses continues to grow. Cardiovascular toxicity was common with older psychiatric medications but seems uncommon with AAPM. We conducted a systematic literature review to describe the cardiovascular effects reported after overdose of 5 common AAPM: aripiprazole, olanzapine, quetiapine, risperidone, and ziprasidone. We included case reports and case series describing overdose of these 5 medications identified in a search of MEDLINE, EMBASE, and abstracts from major toxicology meetings. We found 13 pediatric cases (age, <7 years), 22 adolescent cases (age, 7-16 years), and 185 adult cases. No pediatric case described a ventricular dysrhythmia or a cardiovascular death. In the adolescent and adult cases, we found numerous reports of prolonged corrected QT interval and hypotension, but there were only 3 cases of ventricular dysrhythmia and 3 deaths that may have been due to direct cardiovascular toxicity. The results from case series reports were similar to the single case report data. Our review suggests that overdose of AAPM is unlikely to cause significant cardiovascular toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.