Evidence map›Paper›PMID 19497401›Full record

ReviewSeminars in nuclear medicine2009

Genomic biomarkers for molecular imaging: predicting the future.

Mathew L Thakur

Abstract readReview
In one paragraph

Review in Seminars in nuclear medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. VPAC1 receptors for imaging breast cancer: a feasibility study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Current perspectives in medical image perception.Attention, perception & psychophysics · 2010
    Review
  10. Predictive and prognostic molecular markers for cancer medicine.Therapeutic advances in medical oncology · 2010
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mathew L ThakurLaboratories of Radiopharmaceutical Research and Molecular Imaging, Department of Radiology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Mathew.Thakur@jefferson.edu
Thomas Jefferson University · US

Funding

PET Imaging of Breast Cancer Using Oncogene ExpressionR01CA109231 · NCI · THOMAS JEFFERSON UNIVERSITY · PI THAKUR, MATHEW LAXMAN · 2005 to 2008
$1.6M
Improved Molecular Imaging with SPECTR01EB001809 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI THAKUR, MATHEW LAXMAN · 2003 to 2006
$1.4M
NCI NIH HHS CA 10923NCI NIH HHS N01 CO027175NCI NIH HHS R01 CA109231NIBIB NIH HHS EB001809NIBIB NIH HHS R01 EB001809PHS HHS ISIORR23709PHS HHS PAME03184
6 · The paper itself

Abstract

Over the past few decades, great strides have been made in anatomical imaging of disease that has led to their diagnosis with minimal invasion. Despite these advances, diseases such as cancer continue to take one human life every minute in the United States. Complimentary approaches that pertain directly to the genesis of the disease might contribute to its early diagnosis and subsequent management. In cancer, an array of molecular abnormalities leading to the modulations in expression of key proteins important in the cellular signaling pathways and cell proliferation has been identified. These specific disease fingerprints, biomarkers, are overexpressed on malignant cell surfaces or within the cytoplasm, and they provide unique targets that are promising for improving cancer diagnosis and therapy. We and others have designed, synthesized, and evaluated some novel probes specific for those oncogenes and oncogene product biomarkers for PET and SPECT molecular imaging of certain types of cancers. This article briefly describes this approach and gives specific examples that depict the ability of molecular imaging to detect occult lesions not detectable by current scintigraphic approaches. The article also outlines a few examples predicting other possible applications of targeting such specific probes not yet used.

Indexed as

GenomicsAnimalsBiomarkers, TumorDiagnostic ImagingEarly DiagnosisHumansNeoplasmsBiomarkers, Tumor

Identifiers

PMID19497401
PMCPMC2731478
OpenAlexW1987192010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.