ArticleBMC infectious diseases2009
Characterization of coagulase-negative staphylococcal isolates from blood with reduced susceptibility to glycopeptides and therapeutic options.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 90 citations in OpenAlex.
- Rise in the Pathogenic Status of Coagulase-Negative Staphylococci Causing Bloodstream Infection.Cureus · 2024Article
- Increased incidence of teicoplanin-non-susceptible Staphylococcus epidermidis strains: a 6-year retrospective study.Scientific reports · 2023Article
- Antibiotic Susceptibility Pattern and Bacterial Spectrum Among Patients with External Eye Infections at Menelik II Referral Hospital in Addis Ababa, Ethiopia.Infection and drug resistance · 2022Article
- Epidemiology and Pathogenesis ofPolish journal of microbiology · 2021Review
- Multidrug-Resistant Coagulase-Negative Staphylococci Isolated from Bloodstream in the uMgungundlovu District of KwaZulu-Natal Province in South Africa: Emerging Pathogens.Antibiotics (Basel, Switzerland) · 2021Article
- Evaluation of Teicoplanin Resistance Detected by Automated System in Coagulase Negative Staphylococci: A Comparison with Gradient Test and Broth Microdilution Methods.Current microbiology · 2020Article
- Food-derived coagulase-negativeFood science and biotechnology · 2020Review
- Comparative Genomic Analysis of Food-Originated Coagulase-Negative Staphylococcus: Analysis of Conserved Core Genes and Diversity of the Pan-Genome.Journal of microbiology and biotechnology · 2020Article
- Prevalence and phylogenetic relationship among methicillin- and vancomycin-resistantJournal of advanced veterinary and animal research · 2019Article
- Distribution of staphylococcal cassette chromosomeIranian journal of microbiology · 2018Article
- Article
- Vancomycin heteroresistance in coagulase negative Staphylococcus blood stream infections from patients of intensive care units in Mansoura University Hospitals, Egypt.Annals of clinical microbiology and antimicrobials · 2017Article
- Antibiotic resistance and biofilm formation among coagulase-negative staphylococci isolated from clinical samples at a tertiary care hospital of eastern Nepal.Antimicrobial resistance and infection control · 2017Article
- Epidemiology and prognosis of coagulase-negative staphylococcal endocarditis: impact of vancomycin minimum inhibitory concentration.PloS one · 2015Article
- Prevalence of multidrug resistant Gram-positive cocci in a Chinese hospital over an 8-year period.International journal of clinical and experimental medicine · 2015Article
- Coagulase-negative staphylococci.Clinical microbiology reviews · 2014Review
- In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Trend of vancomycin susceptibility of staphylococci at a level 1 trauma centre of India.The Indian journal of medical research · 2013Article
- Genetic analysis of glycopeptide-resistant Staphylococcus epidermidis strains from bone and joint infections.Journal of clinical microbiology · 2013Article
- Susceptibility of bacterial etiological agents to commonly-used antimicrobial agents in children with sepsis at the Tamale Teaching Hospital.BMC infectious diseases · 2013Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoagulase-negative staphylococci (CoNS) are a major cause of nosocomial blood stream infection, especially in critically ill and haematology patients. CoNS are usually multidrug-resistant and glycopeptide antibiotics have been to date considered the drugs of choice for treatment. The aim of this study was to characterize CoNS with reduced susceptibility to glycopeptides causing blood stream infection (BSI) in critically ill and haematology patients at the University Hospital Tor Vergata, Rome, Italy, in 2007.
methodsHospital microbiology records for transplant haematology and ICU were reviewed to identify CoNS with elevated MICs for glycopeptides, and isolates were matched to clinical records to determine whether the isolates caused a BSI. The isolates were tested for susceptibility to new drugs daptomicin and tigecycline and the genetic relationship was assessed using f-AFLP.
resultsOf a total of 17,418 blood cultures, 1,609 were positive for CoNS and of these, 87 (5.4%) displayed reduced susceptibility to glycopeptides. Clinical review revealed that in 13 cases (7 in haematology and 6 in ICU), CoNS with reduced susceptibility to glycopeptides were responsible for a BSI. Staphylococcus epidermidis was the causative organism in 11 instances and Staphylococcus haemolyticus in 2. The incidence of oxacillin resistance was high (77%), although all isolates remained susceptible to linezolid, daptomycin and tigecycline. Fingerprinting of CoNS identified one clonal relationship between two isolates.
conclusionMulti-resistant CoNS with reduced susceptibility to glycopeptides, although still relatively infrequent in our hospital, are emerging pathogens of clinical concern. Surveillance by antibiotyping with attention to multi-resistant profile, and warning to clinicians, is necessary.
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