ArticleMalaria journal2009
Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.
Article in Malaria journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- TheeLife · 2017Article
- Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato).Parasites & vectors · 2016Article
- Culicoides Latreille (Diptera: Ceratopogonidae) taxonomy: current challenges and future directions.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Population genetics of Anopheles coluzzii immune pathways and genes.G3 (Bethesda, Md.) · 2014Article
- Genome-wide patterns of polymorphism in an inbred line of the African malaria mosquito Anopheles gambiae.Genome biology and evolution · 2014Article
- No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.Evolutionary applications · 2013Article
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development.Development (Cambridge, England) · 2012Article
- Asymmetric introgression between the M and S forms of the malaria vector, Anopheles gambiae, maintains divergence despite extensive hybridization.Molecular ecology · 2011Article
- Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae.BMC evolutionary biology · 2011Article
- Molecular evolution of a gene cluster of serine proteases expressed in the Anopheles gambiae female reproductive tract.BMC evolutionary biology · 2011Article
- Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae.PLoS biology · 2011Article
- Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology.PloS one · 2010Article
- Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum.PLoS pathogens · 2010Article
- The demographic histories of the M and S molecular forms of Anopheles gambiae s.s.Molecular biology and evolution · 2010Article
- Anopheles immune genes and amino acid sites evolving under the effect of positive selection.PloS one · 2010Article
- The population genomics of trans-specific inversion polymorphisms in Anopheles gambiae.Genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusive evidence that any of these mosquito genes evolve rapidly, or show other signatures of adaptive evolution.
methodsThree serine protease inhibitors have previously been identified as candidate immune system genes mediating mosquito-Plasmodium interaction, and serine protease inhibitors have been identified as hot-spots of adaptive evolution in other taxa. Population-genetic tests for selection, including a recent multi-gene extension of the McDonald-Kreitman test, were applied to 16 serine protease inhibitors and 16 other genes sampled from the An. gambiae species complex in both East and West Africa.
resultsSerine protease inhibitors were found to show a marginally significant trend towards higher levels of amino acid diversity than other genes, and display extensive genetic structuring associated with the 2La chromosomal inversion. However, although serpins are candidate targets for strong parasite-mediated selection, no evidence was found for rapid adaptive evolution in these genes.
conclusionIt is well known that phylogenetic and population history in the An. gambiae complex can present special problems for the application of standard population-genetic tests for selection, and this may explain the failure of this study to detect selection acting on serine protease inhibitors. The pitfalls of uncritically applying these tests in this species complex are highlighted, and the future prospects for detecting selection acting on the An. gambiae genome are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.