ArticleInfluenza and other respiratory viruses2009
Antiviral resistance in influenza viruses circulating in Central and South America based on the detection of established genetic markers.
Article in Influenza and other respiratory viruses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Rational Design of Novel Peptidomimetics against Influenza A Virus: Biological and Computational Studies.International journal of molecular sciences · 2023Article
- Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches.PloS one · 2017Article
- Pilot to evaluate the feasibility of measuring seasonal influenza vaccine effectiveness using surveillance platforms in Central-America, 2012.BMC public health · 2015Article
- Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.Antiviral research · 2015Article
- Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?Frontiers in microbiology · 2015Review
- Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013.Antiviral research · 2014Article
- Human parainfluenza virus in patients with influenza-like illness from Central and South America during 2006-2010.Influenza and other respiratory viruses · 2014Article
- Tracking oseltamivir-resistance in New Zealand influenza viruses during a medicine reclassification in 2007, a resistant-virus importation in 2008 and the 2009 pandemic.Western Pacific surveillance and response journal : WPSAR · 2012Article
- Influenza and other respiratory viruses in three Central American countries.Influenza and other respiratory viruses · 2011Article
- Sentinel surveillance of influenza-like-illness in two cities of the tropical country of Ecuador: 2006-2010.PloS one · 2011Article
- Genetic analysis of influenza A/H1N1 of swine origin virus (SOIV) circulating in Central and South America.The American journal of tropical medicine and hygiene · 2010Article
- Oseltamivir resistance in swine influenza: a brief discussion.North American journal of medical sciences · 2009Article
- Influenza-like illness sentinel surveillance in Peru.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent influenza antiviral resistance studies reveal an alarming increase in both adamantanes and neuraminidase inhibitors (NAIs) resistant viral strains worldwide, particularly in Asia, Europe and the United States.
objectivesIn this study, we have evaluated influenza virus resistance in Central and South America.
methodsInfluenza viruses, isolated from symptomatic patients throughout Central and South America in 2005-2008 were analyzed for inhibitor resistance. The M2 and NA genes of influenza viruses were sequenced and resistance was inferred by comparison with published sequences and known resistant mutations.
resultsOur results indicate that: (i) resistance to adamantanes was seen in the majority (95.5%) of the influenza A/H3N2 isolates but only in one isolate of the influenza A/H1N1 viruses; (ii) resistance to NAIs began to be detected in A/H1N1 isolates from Central America in 2008; and (iii) none of the influenza B viruses analyzed were resistant to NAIs.
conclusionsThese findings suggest a limited effectiveness of influenza inhibitors due to the detection of resistance among A/H1 and A/H3 viruses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.