ArticleAntioxidants & redox signaling2009
Association of systemic oxidative stress with suppressed serum IgG to commensal oral biofilm and modulation by periodontal infection.
Article in Antioxidants & redox signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Antibodies to oral pathobionts and colon cancer risk in the CLUE I cohort study.International journal of cancer · 2023Article
- Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in HAntioxidants (Basel, Switzerland) · 2023Article
- Periodontal and Other Oral Bacteria and Risk of Lung Cancer in the Atherosclerosis Risk in Communities (ARIC) Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Association of rs142548867 (EEFSEC) and periodontitis Grade C in a young Brazilian population.Journal of applied oral science : revista FOB · 2023Article
- Article
- Oxidative stress and immune aberrancies in attention-deficit/hyperactivity disorder (ADHD): a case-control comparison.European child & adolescent psychiatry · 2019Article
- Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association.Journal of dental research · 2015Article
- Smoking-related cotinine levels and host responses in chronic periodontitis.Journal of periodontal research · 2014Article
- Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study.Cancer causes & control : CCC · 2013Article
- Periodontal disease immunology: 'double indemnity' in protecting the host.Periodontology 2000 · 2013Review
- Production and Characterization of Mouse Monoclonal Antibodies Recognizing Human Pan-IgG Specific Conformational or Linear Epitopes.Avicenna journal of medical biotechnology · 2012Article
- Smoking and periodontal disease: discrimination of antibody responses to pathogenic and commensal oral bacteria.Clinical and experimental immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To assess the impact of systemic oxidative stress on humoral immune responses, we examined the relation between levels of serum 8-isoprostane and serum IgG antibodies against 17 microorganisms in the commensal oral biofilm among the ARIC population of community-dwelling adults (n = 4,717). Bivariately, serum 8-isoprostane was associated with age, race/center, education, smoking, serum triglycerides, and the extent of periodontal disease severity. Total IgG antibody directed to the oral biofilm was significantly associated with race/center, hypertension, triglycerides, periodontal disease severity, plaque, and serum 8-isoprostane. In multivariate models, the highest quartile of increased 8-isoprostane displayed marked reductions (44%) in biofilm IgG antibody in contrast to small increases in total IgG antibody level for the highest quartiles of oral bacterial burden or periodontal disease severity (19 and 12%, respectively; p < 0.0001). Increased 8-isoprostane was associated with decreased total IgG antibody (p < 0.0001) in subjects with or without extensive periodontal disease and/or biofilm and with suppression of IgG responses across the entire biofilm composition. Increased systemic oxidative stress is associated with a generalized decrease of serum IgG antibody responses to the oral biofilm. Levels of oral microbial burden, periodontitis severity, and smoking are, by comparison, minor modifiers of serum IgG responses to the commensal oral biofilm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.