ReviewDrugs2009
Pharmacological treatment of endometriosis: experience with aromatase inhibitors.
Review in Drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date.Drug design, development and therapy · 2023Pooled it
- Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature.Frontiers in medicine · 2021Pooled it
- Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.Reproductive biology and endocrinology : RB&E · 2011Pooled it
- Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study.Reproductive biology and endocrinology : RB&E · 2019Trial
- Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial.Reproductive biology and endocrinology : RB&E · 2011Trial
- Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents.International journal of women's health · 2024Review
- Nanomedicines for Endometriosis: Lessons Learned from Cancer Research.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
- Molecular Targets for Endometriosis Therapy: Where We Are and Where We Are Going?International journal of fertility & sterility · 2019Article
- Review
- Effect of Letrozole on endometriosis-related pelvic pain.Medical journal of the Islamic Republic of Iran · 2014Article
- Potential role of aromatase inhibitors in the treatment of endometriosis.International journal of women's health · 2014Review
- Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation.The Journal of clinical endocrinology and metabolism · 2013Review
- Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons.Fertility and sterility · 2013Article
- Aromatase inhibitors for the treatment of endometriosis.Fertility and sterility · 2012Review
- Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels.The Journal of clinical endocrinology and metabolism · 2012Article
- Bowel endometriosis: Recent insights and unsolved problems.World journal of gastrointestinal surgery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents. In the last 10 years, it has been demonstrated that aromatase P450, a key enzyme for estrogen biosynthesis, may have a pathogenic role in endometriosis because it is aberrantly expressed in endometriotic implants and in eutopic endometrium of women with endometriosis. Therefore, inhibition of aromatase activity may represent a new therapeutic option for endometriosis. Case reports and observational studies have shown that pain symptoms caused by endometriosis quickly improve after administration of aromatase inhibitors. Limited data are available on the long-term course of pain symptoms after completion of treatment with aromatase inhibitors; however, some recent studies suggest that symptoms may recur at short-term follow-up. A range of results are reported on the effects of aromatase inhibitors on endometriotic lesions, with some authors describing improvements and other authors reporting persistence of pelvic lesions at second-look laparoscopy after treatment. No severe adverse effect has been reported during treatment with aromatase inhibitors both in pre- and postmenopausal women. On the basis of the available data, administration of aromatase inhibitors should now be offered only to the small number of women who have severe pain despite previous surgical and hormonal therapies. Further research in the form of randomized controlled trials will be required before recommending the routine use of these agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.