ArticleJournal of medical entomology2009
Identification and characterization of heat shock 70 genes in Aedes aegypti (Diptera: Culicidae).
Article in Journal of medical entomology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- The Temperature-Associated Effects of Rift Valley Fever Virus Infections in Mosquitoes and Climate-Driven Epidemics: A Review.Viruses · 2025Review
- Validation of heat-inducibleiScience · 2024Article
- Arthropod promoters for genetic control of disease vectors.Trends in parasitology · 2024Review
- Validation of a heat-induciblebioRxiv : the preprint server for biology · 2023Article
- Impact of extrinsic incubation temperature on natural selection during Zika virus infection of Aedes aegypti and Aedes albopictus.PLoS pathogens · 2021Article
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- Temperature modulates immune gene expression in mosquitoes during arbovirus infection.Open biology · 2021Article
- Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Toxicogenome of Hyalella azteca: A Model for Sediment Ecotoxicology and Evolutionary Toxicology.Environmental science & technology · 2018Article
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- The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera.BMC evolutionary biology · 2016Article
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- Robust heat-inducible gene expression by two endogenous hsp70-derived promoters in transgenic Aedes aegypti.Insect molecular biology · 2012Article
- Strain Variation in the Transcriptome of the Dengue Fever Vector, Aedes aegypti.G3 (Bethesda, Md.) · 2012Article
- Drinking a hot blood meal elicits a protective heat shock response in mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Heat shock proteins contribute to mosquito dehydration tolerance.Journal of insect physiology · 2010Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Heat shock genes are highly evolutionarily conserved and are expressed to varying degrees in all organisms in response to stress. Heat shock 70 (hsp70) genes have been well characterized in a number of organisms, most notably Drosophila melanogaster, but not as yet for any of the major arthropod-borne viral mosquito vectors. To identify hsp70 genes in the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae), basic local alignment searches of the Ae. aegypti genome were performed using D. melanogaster Hsp70 protein sequences as query. Two clusters of six previously unannotated AaHsp70 genes were identified and found to be organized into three pairs of nearly identical open reading frames, which mapped to two genomic scaffolds. Consistent with a designation as heat shock genes, no detectable level of expression of AaHsp70 genes was observed under normal rearing conditions (28 degrees C), with robust expression observed with a heat shock of 37-39 degrees C. Northern analysis showed heat-inducible expression of putative AaHsp70 genes at all life stages and in all tissues tested in a time- and temperature-dependent manner. Monitoring of AaHsp70 gene expression levels in field-caught Ae. aegypti may serve as a general marker for stress. In addition, promoter sequences from AaHsp70 genes may be used to control the expression of transgenes in an inducible manner.
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