ArticleThe Journal of comparative neurology2009
Quantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classes.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 40 citations in OpenAlex.
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- An imaging analysis protocol to trace, quantify, and model multi-signal neuron morphology.STAR protocols · 2021Article
- Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind.Brain research · 2018Review
- Name-calling in the hippocampus (and beyond): coming to terms with neuron types and properties.Brain informatics · 2017Article
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- Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.Neuroscience · 2015Article
- The importance of metadata to assess information content in digital reconstructions of neuronal morphology.Cell and tissue research · 2015Article
- Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology.Biophysical journal · 2015Article
- Multi-dimensional classification of GABAergic interneurons with Bayesian network-modeled label uncertainty.Frontiers in computational neuroscience · 2014Article
- Dendritic branch intersections are structurally regulated targets for efficient axonal wiring and synaptic clustering.PloS one · 2013Article
- Digital morphometry of rat cerebellar climbing fibers reveals distinct branch and bouton types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Properties and functional implications of I (h) in hippocampal area CA3 interneurons.Pflugers Archiv : European journal of physiology · 2011Article
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- Article
- The DIADEM data sets: representative light microscopy images of neuronal morphology to advance automation of digital reconstructions.Neuroinformatics · 2011Review
- Multiple forms of long-term synaptic plasticity at hippocampal mossy fiber synapses on interneurons.Neuropharmacology · 2011Review
- Axonal morphometry of hippocampal pyramidal neurons semi-automatically reconstructed after in vivo labeling in different CA3 locations.Brain structure & function · 2011Article
- Potential Synaptic Connectivity of Different Neurons onto Pyramidal Cells in a 3D Reconstruction of the Rat Hippocampus.Frontiers in neuroinformatics · 2011Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The morphological and electrophysiological diversity of inhibitory cells in hippocampal area CA3 may underlie specific computational roles and is not yet fully elucidated. In particular, interneurons with somata in strata radiatum (R) and lacunosum-moleculare (L-M) receive converging stimulation from the dentate gyrus and entorhinal cortex as well as within CA3. Although these cells express different forms of synaptic plasticity, their axonal trees and connectivity are still largely unknown. We investigated the branching and spatial patterns, plus the membrane and synaptic properties, of rat CA3b R and L-M interneurons digitally reconstructed after intracellular labeling. We found considerable variability within but no difference between the two layers, and no correlation between morphological and biophysical properties. Nevertheless, two cell types were identified based on the number of dendritic bifurcations, with significantly different anatomical and electrophysiological features. Axons generally branched an order of magnitude more than dendrites. However, interneurons on both sides of the R/L-M boundary revealed surprisingly modular axodendritic arborizations with consistently uniform local branch geometry. Both axons and dendrites followed a lamellar organization, and axons displayed a spatial preference toward the fissure. Moreover, only a small fraction of the axonal arbor extended to the outer portion of the invaded volume, and tended to return toward the proximal region. In contrast, dendritic trees demonstrated more limited but isotropic volume occupancy. These results suggest a role of predominantly local feedforward and lateral inhibitory control for both R and L-M interneurons. Such a role may be essential to balance the extensive recurrent excitation of area CA3 underlying hippocampal autoassociative memory function.
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