ArticleDigestive diseases and sciences2010
Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- The immunopathogenesis ofFrontiers in microbiology · 2024Review
- Animal Models andJournal of clinical medicine · 2022Review
- The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022Review
- The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer.Frontiers in immunology · 2022Review
- Roles of Eicosanoids in Regulating Inflammation and Neutrophil Migration as an Innate Host Response to Bacterial Infections.Infection and immunity · 2021Article
- Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide andOxidative medicine and cellular longevity · 2021Article
- Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro.Journal of microbiology (Seoul, Korea) · 2020Article
- Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer.Scientific reports · 2020Article
- Article
- Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan againstJournal of veterinary science · 2020Article
- Gastric cancer: genome damaged by bugs.Oncogene · 2020Review
- Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers.Antioxidants & redox signaling · 2017Review
- Gastroprotective and gastric motility benefits of AD-lico/Healthy Gut™Animal cells and systems · 2017Article
- Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers.Experimental and therapeutic medicine · 2016Article
- JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression.Oncotarget · 2016Article
- ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2.The Biochemical journal · 2016Article
- The Immune Battle against Helicobacter pylori Infection: NO Offense.Trends in microbiology · 2016Review
- Jak1/Stat3 is an upstream signaling of NF-κB activation in Helicobacter pylori-induced IL-8 production in gastric epithelial AGS cells.Yonsei medical journal · 2015Article
- Medicinal plant activity on Helicobacter pylori related diseases.World journal of gastroenterology · 2014Review
- Role of cyclooxygenase-2 in gastric cancer development and progression.World journal of gastroenterology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. The genetic differences of H. pylori isolates play a role in the clinical outcome of the infection. Inflammatory genes including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are involved in H. pylori gastritis. Transcription factor AP-1 is composed of c-Fos and c-Jun and mediates inflammation and carcinogenesis. Ras acts as a regulator for AP-1 activation in various cells. We investigated whether H. pylori in a Korean isolate (HP99), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99-induced expressions of COX-2 and iNOS are mediated by Ras and AP-1, determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras (ras N-17) and c-Jun (TAM-67). As a result, HP99 induced the expression of c-Fos and c-Jun and the expressions of COX-2 and iNOS in AGS cells. Transfection with mutant genes for Ras or c-Jun suppressed HP99-induced expressions of COX-2 and iNOS in AGS cells. In conclusion, H. pylori in a Korean isolate induces the expression of COX-2 and iNOS via AP-1 activation, which may be mediated by Ras and the expression of c-Fos and c-Jun in gastric epithelial cells.
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Registered trials
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