ArticleNeurochemical research2009
Free radical generation by neurons in rat model of Japanese encephalitis.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Viruses and psychiatric disorders: We have not crossed the borderline from hypothesis to proof yet (Review).Molecular medicine reports · 2025Review
- Underestimated virus impaired cognition-more evidence and more work to do.Frontiers in immunology · 2025Review
- Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection.Molecular neurobiology · 2024Review
- Japanese Encephalitis Virus Infection Causes an Imbalance in the Activation of Mitochondrial Fusion/Fission Genes and Triggers the Activation of NOX2-mediated Oxidative Stress and Neuronal Cell Death.Neurochemical research · 2023Article
- Reactive Oxygen Species (ROS) Are Not a Key Determinant for Zika Virus-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells.Viruses · 2021Article
- Elevation of Cleaved p18 Bax Levels Associated with the Kinetics of Neuronal Cell Death during Japanese Encephalitis Virus Infection.International journal of molecular sciences · 2019Article
- Predictors and outcome of status epilepticus in cerebral venous thrombosis.Journal of neurology · 2019Article
- Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy.Experimental neurology · 2015Article
- Biomarkers in Japanese encephalitis: a review.BioMed research international · 2013Review
- Temporal changes of Japanese encephalitits virus in different brain regions of rat.The Indian journal of medical research · 2013Article
- Status of proinflammatory and anti-inflammatory cytokines in different brain regions of a rat model of Japanese encephalitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased generation of free radicals resulting in brain injury is a feature of many viral infections. The present study has been undertaken to evaluate the level of free radicals in Japanese encephalitis. Twelve days old Wistar rats were inoculated intracerebrally with 3 x 10(6) pfu of JE virus and were sacrificed on 3, 6, 10, and 20 days post inoculation (dpi). The neuronal levels of reactive oxygen species (ROS), nitric oxide (NO), peroxinitrite (OONO(-)), necrotic and apoptotic cell population were estimated by flow cytometry. Hematoxylin-eosin staining was also performed. Maximum level of neuronal ROS and OONO(-) was observed on 6 dpi; however, NO levels peaked on 10 dpi. Free radical generation significantly declined on 20 dpi as compared to control. Apoptotic cell death gradually increased over the time. Neuronal shrinkage and necrosis was also observed. The results of our study indicate that free radicals increased in acute JE and declined at later stage, which may contribute to cell death.
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