ArticlePsychopharmacology2009
Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Editorial: Sleep and circadian rhythm disruptions associated with substance use disorders.Frontiers in neuroscience · 2023Article
- Early Life Stress Promotes Heroin Seeking But Does Not Alter the Excitability of Insular Pyramidal Cells Targeting the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2021Article
- Synthetic cathinone self-administration in female rats modulates neurotransmitter levels in addiction-related brain regions.Behavioural brain research · 2019Article
- Analysis of neurotransmitter levels in addiction-related brain regions during synthetic cathinone self-administration in male Sprague-Dawley rats.Psychopharmacology · 2019Article
- Oxycodone self-administration during pregnancy disrupts the maternal-infant dyad and decreases midbrain OPRM1 expression during early postnatal development in rats.Pharmacology, biochemistry, and behavior · 2018Article
- Assessing alcohol and nicotine co-consumption in mice.Oncotarget · 2017Article
- Voluntary co-consumption of alcohol and nicotine: Effects of abstinence, intermittency, and withdrawal in mice.Neuropharmacology · 2016Article
- The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Distinct neurochemical adaptations within the nucleus accumbens produced by a history of self-administered vs non-contingently administered intravenous methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Repeated mirtazapine nullifies the maintenance of previously established methamphetamine-induced conditioned place preference in rats.Behavioural brain research · 2011Article
- Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice.Psychopharmacology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThere is evidence demonstrating changes in dopamine (DA) transmission in the nucleus accumbens (NAc) related to contingent versus non-contingent drug administration.
objectivesThe aim of this study was to evaluate basal and 3,4-methylenedioxymethamphetamine (MDMA)-stimulated DA levels in the NAc of mice that had previously received contingent and non-contingent infusions of MDMA. Contingent mice were trained to self-administer MDMA (0.125 mg/kg/infusion) in 2-h sessions for 10 days. Yoked mice received either MDMA at the same dose or saline. Forty-eight hours after the last MDMA or saline administration, DA levels were measured by in vivo microdialysis before and after an MDMA (10 mg/kg, i.p.) challenge. Binding of [(3)H]-mazindol and [(3)H]-citalopram was evaluated by autoradiography.
resultsAnimals receiving MDMA infusions showed significantly lower basal DA levels than the yoked saline group. A reduced activation of DA was observed following MDMA in contingent mice with respect to both yoked MDMA and saline mice. No significant alterations in DA transporter or serotonin transporter were observed in the three groups of mice.
conclusionsThese results suggest that prolonged exposure to MDMA in mice produces changes in basal DA levels after drug withdrawal and a decreased neurochemical response at the level of the mesolimbic DA reward pathway that is, in part, related to instrumental learning during self-administration.
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