ArticleJournal of molecular evolution2009
The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).The Biochemical journal · 2025Review
- Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2.Computational and structural biotechnology journal · 2023Article
- The pseudokinase domain in receptor guanylyl cyclases.Methods in enzymology · 2022Review
- Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach.American journal of medical genetics. Part A · 2021Article
- Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.Biomarkers in medicine · 2021Review
- Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations.IUBMB life · 2020Review
- The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.Science signaling · 2019Article
- Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase.Cell host & microbe · 2018Article
- Nucleotide-binding mechanisms in pseudokinases.Bioscience reports · 2015Review
- Conserved Functional Motifs and Homology Modeling to Predict Hidden Moonlighting Functional Sites.Frontiers in bioengineering and biotechnology · 2015Review
- From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Mutational analysis gives insight into substrate preferences of a nucleotidyl cyclase from Mycobacterium avium.PloS one · 2014Article
- A cyclic nucleotide sensitive promoter reporter system suitable for bacteria and plant cells.BMC biotechnology · 2013Article
- Moonlighting kinases with guanylate cyclase activity can tune regulatory signal networks.Plant signaling & behavior · 2012Article
- Functional and evolutionary aspects of chemoreceptors.Frontiers in cellular neuroscience · 2012Article
- The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants.The Journal of biological chemistry · 2011Article
- Cyclic GMP controls Rhodospirillum centenum cyst development.Molecular microbiology · 2011Article
- Review
- 17Beta-estradiol elevates cGMP and, via plasma membrane recruitment of protein kinase GIalpha, stimulates Ca2+ efflux from rat hepatocytes.The Journal of biological chemistry · 2010Article
- The S helix mediates signal transmission as a HAMP domain coiled-coil extension in the NarX nitrate sensor from Escherichia coli K-12.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guanylyl cyclases (GCs) are enzymes that generate cyclic GMP and regulate different physiologic and developmental processes in a number of organisms. GCs possess sequence similarity to class III adenylyl cyclases (ACs) and are present as either membrane-bound receptor GCs or cytosolic soluble GCs. We sought to determine the evolution of GCs using a large-scale bioinformatic analysis and found multiple lineage-specific expansions of GC genes in the genomes of many eukaryotes. Moreover, a few GC-like proteins were identified in prokaryotes, which come fused to a number of different domains, suggesting allosteric regulation of nucleotide cyclase activity. Eukaryotic receptor GCs are associated with a kinase homology domain (KHD), and phylogenetic analysis of these proteins suggest coevolution of the KHD and the associated cyclase domain as well as a conservation of the sequence and the size of the linker region between the KHD and the associated cyclase domain. Finally, we also report the existence of mimiviral proteins that contain putative active kinase domains associated with a cyclase domain, which could suggest early evolution of the fusion of these two important domains involved in signal transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.