ArticleLab on a chip2009
Selective and tunable gradient device for cell culture and chemotaxis study.
Article in Lab on a chip, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery.Pharmaceutics · 2023Review
- Microfluidic devices for neutrophil chemotaxis studies.Journal of translational medicine · 2020Review
- In Vitro Immune Organs-on-Chip for Drug Development: A Review.Pharmaceutics · 2018Review
- Quantitative analysis of B-lymphocyte migration directed by CXCL13.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Gradient generation platforms: new directions for an established microfluidic technology.Lab on a chip · 2014Article
- Microfluidic transwell inserts for generation of tissue culture-friendly gradients in well plates.Lab on a chip · 2014Article
- Cell motility and drug gradients in the emergence of resistance to chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Enabling systems biology approaches through microfabricated systems.Analytical chemistry · 2013Article
- Sequentially pulsed fluid delivery to establish soluble gradients within a scalable microfluidic chamber array.Biomicrofluidics · 2013Article
- Microfluidic devices for cell cultivation and proliferation.Biomicrofluidics · 2013Review
- Biomimetic approaches to control soluble concentration gradients in biomaterials.Macromolecular bioscience · 2011Review
- Nanofibrous scaffold with incorporated protein gradient for directing neurite outgrowth.Drug delivery and translational research · 2011Article
- A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment.Biomedical microdevices · 2010Article
- Microchannel-nanopore device for bacterial chemotaxis assays.Analytical chemistry · 2010Article
- Microfluidic technologies for temporal perturbations of chemotaxis.Annual review of biomedical engineering · 2010Review
- Article
- Fundamentals of microfluidic cell culture in controlled microenvironments.Chemical Society reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This article describes a microfluidic device for cell culture and chemotaxis studies under various temporal and spatial concentration gradients of the medium or chemoattractant. Vertical membranes formed using in situ fabrication are employed to avoid fluid flow inside the cell observation chamber. Thus, the medium and chemoattractants are primarily provided by diffusion, maintaining cell-cell communication via secreted factors. Neutrophils were used to demonstrate the capability of the device for chemotaxis research. Experiments exhibited successful migration up a concentration gradient of interleukin 8.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.