ArticleNature2009
Attrition of memory CD8 T cells.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Effect of cellular aging on memory T-cell homeostasis.Frontiers in immunology · 2022Article
- Clonal expansion of innate and adaptive lymphocytes.Nature reviews. Immunology · 2020Review
- How age and infection history shape the antigen-specific CD8Aging cell · 2020Review
- Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner.The Journal of experimental medicine · 2019Article
- Article
- Interactions between innate and adaptive lymphocytes.Nature reviews. Immunology · 2014Review
- Trace amounts of sporadically reappearing HCV RNA can cause infection.The Journal of clinical investigation · 2014Article
- The two faces of heterologous immunity: protection or immunopathology.Journal of leukocyte biology · 2014Review
- CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model.Frontiers in microbiology · 2014Review
- Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.Journal of virology · 2013Article
- Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Theoretical analysis of the evolution of immune memory.BMC evolutionary biology · 2010Article
- Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Heterologous immunity between viruses.Immunological reviews · 2010Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
An important role for the immune system is to maintain protective immunological memory to a wide variety of pathogens encountered over one's lifetime, while still leaving the host able to respond to newly encountered pathogens. Vezys et al. make the interesting observation that it is possible to repeatedly immunize mice in ways that allow for development of high numbers of memory CD8 T cells without depleting pre-existing memory cells specific for other pathogens. This study, which offers promise in developing potent vaccination schemes, is seemingly at odds with work published by us in the 1990s showing a loss in CD8 memory cells after a series of infections. In their reply, Vezys et al. mention that we may have misinterpreted our data because we reported the putative loss of memory T cells as per cent rather than total number, but here we represent the data in those studies as total cell number. We show here in Fig. 1 that a series of infections can indeed reduce the total number of memory cells, indicating that vaccination strategies need to consider this issue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.