Evidence map›Paper›PMID 19494810›Full record

Trial reportClinical pharmacology and therapeutics2009

Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients.

I B Skottheim, K Stormark, H Christensen, G S Jakobsen, J Hjelmesaeth, T Jenssen, J L E Reubsaet, R Sandbu, A Asberg

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical pharmacology and therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03571802 phase4unknown statusstarted 2018, after this paper: background citation

The Need of Dosing Adjustment for Simvastatin in Obese Patients Post Bariatric Surgery- Laparoscopic Sleeve Gastrectomy (LSG)

Ran2018Enrolled10Registered outcomes6Posted comparisons0ConditionsHyperlipidemias, ObesityArmssimvastatin
PMID 23247745other papers from this trial
Open the trial in the graph
NCT01317147 completednot on this map

The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors

TypeobservationalSponsorUniversity of PittsburghRan2007 to 2010Enrolled12ConditionsGastric Bypass, Depression, Anxiety DisorderArmsRoux-en-Y gastric bypass (RYGBP)
NCT02641301 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

Study of the Concentrations of Long Acting Morphine After Oral Absorption in Subjects Who Underwent Gastric Bypass (OBEMO 2)

TypeinterventionalSponsorHopital LariboisièreRan2015 to 2017Enrolled24ConditionsBypass ComplicationsArmsSustained release morphine sulfate, 30 mg
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

I B SkottheimDepartment of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.
K Stormark
H Christensen
G S Jakobsen
J Hjelmesaeth
T Jenssen
J L E Reubsaet
R Sandbu
A Asberg
Sykehuset i Vestfold · NOUniversity of Oslo · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of gastric bypass on atorvastatin pharmacokinetics was investigated in 12 morbidly obese patients being treated with 20-80 mg atorvastatin each morning. Eight-hour pharmacokinetic investigations were performed the day before the surgery and at a median of 5 weeks (range 3-6 weeks) after the surgery. Gastric bypass surgery produced a variable effect on individual systemic exposure to atorvastatin acid (area under the plasma concentration vs. time curve from 0 to 8 h postdose (AUC(0-8))), ranging from a threefold decrease to a twofold increase (median ratio = 1.1, P = 0.99). Patients with the highest systemic exposure to atorvastatin before surgery showed reduced exposure after surgery (n = 3, median ratio = 0.4, range = 0.3-0.5, P < 0.01), whereas those with lower systemic exposure before surgery showed a median 1.2-fold increase in atorvastatin AUC(0-8) (n = 9, range = 0.8-2.3, P = 0.03) after surgery. This study indicates that the presurgical first-pass metabolic capacity influences the effect of gastric bypass on atorvastatin bioavailability. Because individual first-pass metabolic capacity is not readily assessable clinically, retitration up to the lowest effective dose should be performed after the surgery.

Indexed as

Gastric BypassAcidsAdultArea Under CurveAtorvastatinATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Biological AvailabilityCytochrome P-450 CYP3ADNAFemaleGenotypeHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLactonesABCB1 protein, humanAcidsAtorvastatinATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1CYP3A5 protein, humanCytochrome P-450 CYP3ADNAHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsLactonesPyrroles

Identifiers

PMID19494810
OpenAlexW2094278352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.