ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2009
Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HTPharmacological reports : PR · 2023Article
- The "Janus-like" RNA-editing machinery in innate antiviral immunity.Current trends in immunology · 2022Article
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition.Human molecular genetics · 2019Article
- Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response.Neuroscience letters · 2018Article
- Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.Psychopharmacology · 2018Article
- Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior.Genes, brain, and behavior · 2018Article
- A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations.BMC genomics · 2018Article
- The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.ERJ open research · 2018Article
- Pharmacological evidence that 5-HTPsychopharmacology · 2017Article
- A short history of the 5-HTPsychopharmacology · 2017Review
- RNA-binding proteins, neural development and the addictions.Genes, brain, and behavior · 2016Review
- Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.Scientific reports · 2015Article
- An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1).Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites.Nucleic acids research · 2014Article
- Serotonin 2c receptor RNA editing in major depression and suicide.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Article
- Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.Biological psychiatry · 2013Article
- Serotonin2C receptors and drug addiction: focus on cocaine.Experimental brain research · 2013Review
- Comparative RNA editing in autistic and neurotypical cerebella.Molecular psychiatry · 2013Article
- Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows.BMC neuroscience · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonin 2C receptor (5-HT(2C)R) exerts a major inhibitory influence on dopamine (DA) neurotransmission within the mesocorticolimbic DA pathway that is implicated in drug reward and goal-directed behaviors. 5-HT(2C)R pre-mRNA undergoes adenosine-to-inosine editing, generating numerous receptor isoforms in brain. As editing influences 5-HT(2C)R activity, individual differences in editing might influence dopaminergic function and, thereby, contribute to interindividual vulnerability to drug addiction. Liability to drug-related behaviors in rats can be predicted by their level of motor activity in response to a novel environment. Rats with a high locomotor response (high responders; HRs) exhibit enhanced acquisition and maintenance of drug self-administration compared to rats with a low response (low responders; LRs). We here examined 5-HT(2C)R mRNA editing and expression in HR and LR phenotypes to investigate the relationship between 5-HT(2C)R function and behavioral traits relevant to drug addiction vulnerability. Three regions of the mesocorticolimbic circuitry (ventral tegmental area (VTA), nucleus accumbens (NuAc) shell, and medial prefrontal cortex (PFC)) were examined. 5-HT(2C)R mRNA expression and editing were significantly higher in the NuAc shell compared with both the PFC and VTA, implying significant differences in function (including constitutive activity) among 5-HT(2C)R neuronal populations within the circuitry. The regional differences in editing could, at least in part, arise from the variations in expression levels of the editing enzyme, ADAR2, and/or from the variations in the ADAR2/ADAR1 ratio observed in the study. No differences in the 5-HT(2C)R expression were detected between the behavioral phenotypes. However, editing was higher in the PFC of HRs vs LRs, implicating this region in the pathophysiology of drug abuse liability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.