ArticleJournal of immunology (Baltimore, Md. : 1950)2009
HSP90alpha and HSP90beta isoforms selectively modulate MHC class II antigen presentation in B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- Identification of common key genes and pathways between type 1 diabetes and multiple sclerosis using transcriptome and interactome analysis.Endocrine · 2020Article
- The Role of Heat Shock Proteins in Type 1 Diabetes.Frontiers in immunology · 2020Review
- Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1.Frontiers in immunology · 2019Article
- Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy.International journal of molecular sciences · 2018Review
- A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.JCI insight · 2018Article
- LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.Molecular immunology · 2015Review
- Endogenous Antigen Presentation of MHC Class II Epitopes through Non-Autophagic Pathways.Frontiers in immunology · 2015Review
- Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.PloS one · 2014Article
- Identification of the cellular sentinels for native immunogenic heat shock proteins in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally.International review of cell and molecular biology · 2013Review
- Pathways of antigen processing.Annual review of immunology · 2013Review
- The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking.Molecular pharmaceutics · 2012Article
- Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus.Annals of the rheumatic diseases · 2011Article
- Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.BMC cancer · 2010Article
- Autophagy and adaptive immunity.Immunology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Two isoforms of heat shock protein (HSP) 90, alpha and beta, are abundantly expressed in the cytoplasm of cells, yet only HSP90alpha serves as a chaperone to potentiate epitope presentation in the context of MHC class I molecules. By contrast, the role of HSP90 isoforms in MHC class II presentation of exogenous and endogenous Ags remains less clear. Studies here using human B lymphoblasts demonstrate the importance of HSP90alpha and HSP90beta isoforms in selectively regulating class II presentation of the diabetes autoantigen glutamic acid decarboxylase (GAD). Inactivation of HSP90 function using geldanamycin or radicicol inhibited MHC class II presentation of exogenous and endogenous GAD, but did not perturb the presentation of several other intra- and extracellular Ags. Treatment of human B cells with geldanamycin and radicicol did not alter cellular MHC class II expression, but did induce a stress response in these APCs. Yet, cell stress alone failed to perturb MHC class II presentation of GAD. HSP90 was found to associate with select Ags such as GAD in cells and ex vivo. Knockdown of HSP90alpha or HSP90beta expression using small interfering RNA decreased the abundance of each isoform, respectively, but did not affect MHC class II expression or induce a stress response. Notably, disruption of HSP90alpha or HSP90beta expression specifically inhibited class II presentation of the exogenous and endogenous GAD Ag. Precomplexing HSP90 with GAD Ag enhanced exogenous GAD Ag presentation. These results demonstrate a requirement for HSP90alpha and HSP90beta in regulating class II presentation of select Ags.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.