ArticleJournal of neurophysiology2009
Activation of the tonic GABAC receptor current in retinal bipolar cell terminals by nonvesicular GABA release.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit.Journal of neurophysiology · 2021Article
- Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Effects of Ethanol on Sensory Inputs to the Medial Giant Interneurons of Crayfish.Frontiers in physiology · 2018Article
- In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing.Experimental eye research · 2015Article
- GABAρ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type.Frontiers in neural circuits · 2014Review
- Independent control of reciprocal and lateral inhibition at the axon terminal of retinal bipolar cells.The Journal of physiology · 2013Article
- Nitric oxide potentiation of the homomeric ρ1 GABA(C) receptor function.British journal of pharmacology · 2012Article
- Divergence of visual channels in the inner retina.Nature neuroscience · 2012Article
- Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons.Neuroscience · 2012Article
- Dopamine and serotonin modulate human GABAρ1 receptors expressed in Xenopus laevis oocytes.ACS chemical neuroscience · 2012Article
- GABA metabolism and transport: effects on synaptic efficacy.Neural plasticity · 2012Review
- Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.Neuron · 2011Article
- GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.Molecular neurobiology · 2011Review
- Allosteric modulation of retinal GABA receptors by ascorbic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Pharmacological analysis of the activation and receptor properties of the tonic GABA(C)R current in retinal bipolar cell terminals.PloS one · 2011Article
- An Update on GABAρ Receptors.Current neuropharmacology · 2010Article
- Immunocytochemical evidence that monkey rod bipolar cells use GABA.The European journal of neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Within the second synaptic layer of the retina, bipolar cell (BC) output to ganglion cells is regulated by inhibitory input to BC axon terminals. GABA(A) receptors (GABA(A)Rs) mediate rapid synaptic currents in BC terminals, whereas GABA(C) receptors (GABA(C)Rs) mediate slow evoked currents and a tonic current, which is strongly regulated by GAT-1 GABA transporters. We have used voltage-clamp recordings from BC terminals in goldfish retinal slices to determine the source of GABA for activation of these currents. Inhibition of vesicular release with concanamycin A or tetanus toxin significantly inhibited GABA(A)R inhibitory postsynaptic currents and glutamate-evoked GABA(A)R and GABA(C)R currents but did not reduce the tonic GABA(C)R current, which was also not dependent on extracellular Ca(2+). The tonic current was strongly potentiated by inhibition of GABA transaminase, under both normal and Ca(2+)-free conditions, and was activated by exogenous taurine; however inhibition of taurine transport had little effect. The tonic current was unaffected by GAT-2/3 inhibition and was potentiated by GAT-1 inhibition even in the absence of vesicular release, indicating that it is unlikely to be evoked by reversal of GABA transporters or by ambient GABA. In addition, GABA release does not appear to occur via hemichannels or P2X(7) receptors. BC terminals therefore exhibit two forms of GABA(C)R-mediated inhibition, activated by vesicular and by nonvesicular GABA release, which are likely to have distinct functions in visual signal processing. The tonic GABA(C)R current in BC terminals exhibits similar properties to tonic GABA(A)R and glutamate receptor currents in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.