ArticleThe Journal of nutrition2009
Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants.Pediatric research · 2016Trial
- Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29 wk.Pediatric research · 2013Trial
- Transplacental supply of mannose and inositol in uncomplicated pregnancies using stable isotopes.The Journal of clinical endocrinology and metabolism · 2012Trial
- Anti-Inflammatory Role of Myo-Inositol in Obesity: Suppression of TNF-α-Induced Inflammation and Monocyte Adhesion in Hypertrophic Human Adipocytes.Food science & nutrition · 2025Article
- Protective Effect of myo-Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish.Neurotoxicity research · 2025Article
- Wide-genome selection of lactic acid bacteria harboring genes that promote the elimination of antinutritional factors.Frontiers in plant science · 2023Article
- Comparison of Hepatic Metabolite Profiles between Infant and Adult Male Mice UsingMetabolites · 2022Article
- Blood myo-inositol concentrations in preterm and term infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Myo-inositol: its metabolism and potential implications for poultry nutrition-a review.Poultry science · 2020Review
- Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.The Journal of physiology · 2018Article
- Inositol Analysis by HPLC and Its Stability in Scavenged Sample Conditions.Medicinal chemistry · 2015Article
- Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep.Journal of animal science and biotechnology · 2014Article
- PCR screening and sequence analysis of iol clusters in Lactobacillus casei strains isolated from koumiss.Folia microbiologica · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonglucose carbohydrates such as mannose and inositol are important in early growth and development, although little is known about their metabolism. Our aim in this study was to determine the plasma appearance rates (Ra) for mannose and inositol in newborns as an index of utilization and as an improved guide to supplementation practices. We studied late-preterm (n = 9) and term (n = 5) infants (median 34 wk gestation, range 33-41 wk) using a multiple isotope infusion start time protocol to determine Ra for each carbohydrate. The plasma mannose concentration [median (range)] was 69.83 (48.60-111.75) micromol/L and the Ra was 0.59 (0.42-0.98) micromol x kg(-1) x min(-1) (854 micromol x kg(-1) x d(-1)). The plasma inositol concentration was 175.74 (59.71-300.60) micromol/L and Ra was 1.06 (0.33-1.75) micromol x kg(-1).min(-1) (1521 micromol x kg(-1) x d(-1)). The Ra for mannose and inositol are >10-fold higher than the amounts a breast-fed infant typically ingests, which are approximately 6 micromol x kg(-1) x d(-1) mannose and 150 micromol x kg(-1) x d(-1) inositol. Thus, for both mannose and inositol, the newborn infant must produce these compounds from glucose at rates sufficient to meet nutritional requirements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.