ArticleJournal of the American Society for Mass Spectrometry2009
An ion trap-ion mobility-time of flight mass spectrometer with three ion sources for ion/ion reactions.
Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Recent Developments in Gas-Phase Ion/Ion Reactions for Analytical Mass Spectrometry.Analytical chemistry · 2020Review
- Conformational Landscapes of Ubiquitin, Cytochrome c, and Myoglobin: Uniform Field Ion Mobility Measurements in Helium and Nitrogen Drift Gas.International journal of mass spectrometry · 2018Article
- Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin.Journal of the American Society for Mass Spectrometry · 2017Article
- Gas-phase protein conformation/multimer ion formation by electrospray ion mobility-mass spectrometry: bovine insulin and ubiquitin.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Folding of Protein Ions in the Gas Phase after Cation-to-Anion Proton-Transfer Reactions.Journal of the American Chemical Society · 2016Article
- Modular calibrant sets for the structural analysis of nucleic acids by ion mobility spectrometry mass spectrometry.The Analyst · 2016Article
- Analysis of Native-Like Proteins and Protein Complexes Using Cation to Anion Proton Transfer Reactions (CAPTR).Journal of the American Society for Mass Spectrometry · 2015Article
- Ion mobility-mass spectrometry reveals conformational changes in charge reduced multiprotein complexes.Journal of the American Society for Mass Spectrometry · 2011Article
- Effects of ion/ion proton transfer reactions on conformation of gas-phase cytochrome c ions.Journal of the American Society for Mass Spectrometry · 2010Article
- A linear ion trap mass spectrometer with versatile control and data acquisition for ion/ion reactions.Journal of the American Society for Mass Spectrometry · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This instrument combines the capabilities of ion/ion reactions with ion mobility (IM) and time-of-flight (TOF) measurements for conformation studies and top-down analysis of large biomolecules. Ubiquitin ions from either of two electrospray ionization (ESI) sources are stored in a three dimensional (3D) ion trap (IT) and reacted with negative ions from atmospheric sampling glow discharge ionization (ASGDI). The proton transfer reaction products are then separated by IM and analyzed via a TOF mass analyzer. In this way, ubiquitin +7 ions are converted to lower charge states down to +1; the ions in lower charge states tend to be in compact conformations with cross sections down to approximately 880 A(2). The duration and magnitude of the ion ejection pulse on the IT exit and the entrance voltage on the IM drift tube can affect the measured distribution of conformers for ubiquitin +7 and +6. Alternatively, protein ions are fragmented by collision-induced dissociation (CID) in the IT, followed by ion/ion reactions to reduce the charge states of the CID product ions, thus simplifying assignment of charge states and fragments using the mobility-resolved tandem mass spectrum. Instrument characteristics and the use of a new ion trap controller and software modifications to control the entire instrument are described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.