Evidence map›Paper›PMID 19493579›Full record

Trial reportInternational journal of cardiology2010

Persistent comorbid symptoms of depression and anxiety predict mortality in heart disease.

Lynn V Doering, Debra K Moser, Barbara Riegel, Sharon McKinley, Patricia Davidson, Heather Baker, Hendrika Meischke, Kathleen Dracup

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05853250 (Clinical), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05853250 nacompletednot on this mapstarted 2017, after this paper: background citation

Clinical (Sleep, Pain and Atrial Fibrillation) and Hospital Stay Effects of Reiki and Manual Therapy After Open Heart Surgery

TypeinterventionalSponsorThe Cleveland ClinicRan2017 to 2020Enrolled272ConditionsCoronary Artery Diseases, Valvular Heart DiseasesArmsReiki/manual therapy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 3 countries.

Lynn V DoeringUniversity of California, Los Angeles Los Angeles, CA, United States. Electronic address: ldoering@sonnet.ucla.edu.
Debra K MoserUniversity of Kentucky, Lexington, CA, United States.
Barbara RiegelUniversity of Pennsylvania, Philadelphia, PA, United States.
Sharon McKinleyUniversity of Technology, Sydney, Australia.
Patricia DavidsonCurtin University of Technology, Sydney, Australia.
Heather BakerUniversity of Auckland, Auckland, New Zealand.
Hendrika MeischkeUniversity of Washington, Seattle, Washington, United States.
Kathleen DracupUniversity of California, San Francisco, San Francisco, CA, United States.
Curtin University · AUUniversity of Auckland · NZUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Kentucky · USUniversity of Pennsylvania · USUniversity of Technology Sydney · AUUniversity of Washington · US

Funding

Reducing Prehospital Delay Acute Myocardial InfarctionR01NR007952 · NINR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI DRACUP, KATHLEEN A · 2001 to 2005
$2.5M
NINR NIH HHS R01 NR007952NINR NIH HHS R01 NR05323
6 · The paper itself

Abstract

backgroundIncident anxiety and depression are associated separately with cardiac events and mortality in patients after acute coronary syndromes, but the influence of persistent comorbid depression and anxiety on mortality remains unknown. The purpose of this study was to determine the prevalence of comorbid persistent depressive and anxious symptoms in individuals with ischemic heart disease and to evaluate effects on mortality.

methodsProspective, longitudinal cohort design in the context of a randomized trial to decrease patient delay in seeking treatment for ischemic heart symptoms (PROMOTION trial) was used, with twelve-month follow-up of 2325 individuals with stable ischemic heart disease. Participants were assessed on enrollment and at 3 months using the Multiple Adjective Affect Checklist and the Brief Symptom Inventory for depressive and anxious symptoms, respectively.

resultsAt 3 months, 608 individuals (61.7%) reported persistent symptoms of depression, anxiety, or both. Three hundred seventy-nine (42.5%) and 1056 (45.4%) had persistent anxious and depressive symptoms, respectively. Those with persistent, comorbid symptoms had higher mortality compared to others (p=.029). The combined presence of anxious and depressive symptoms contributed significantly to mortality when compared to symptom-free participants (OR 2.35, 95% CI 1.23-4.47, p=.010). The presence of persistent depressive symptoms only and persistent anxious symptoms only were not associated with death, when other demographic and clinical variables were considered.

conclusionsPersistent symptoms of anxiety and depression increased substantially the risk of death in patients with ischemic heart disease. Future research into shared and unique pathways and treatments is needed.

Indexed as

AgedAged, 80 and overAnxietyCohort StudiesComorbidityDepressionFemaleHeart DiseasesHumansLongitudinal StudiesMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk Factors

Identifiers

PMID19493579
PMCPMC2998562
OpenAlexW2021134733

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.