ArticleBMC microbiology2009
Polymorphism and selection of rpoS in pathogenic Escherichia coli.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Genome-wide screen of genetic determinants that govern Escherichia coli growth and persistence in lake water.The ISME journal · 2024Article
- Proton motive force underpins respiration-mediated potentiation of aminoglycoside lethality in pathogenic Escherichia coli.Archives of microbiology · 2022Article
- RpoS contributes in a host-dependent manner toFrontiers in microbiology · 2022Article
- Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection.eLife · 2021Article
- Effects of the Quinone Oxidoreductase WrbA onAntioxidants (Basel, Switzerland) · 2021Article
- A stress-induced block in dicarboxylate uptake and utilization inJournal of bacteriology · 2021Article
- Function, Evolution, and Composition of the RpoS Regulon inFrontiers in microbiology · 2020Review
- Inactivation of Transcriptional Regulators during Within-Household Evolution of Escherichia coli.Journal of bacteriology · 2017Article
- Hydrophobicity of Residue 128 of the Stress-Inducible Sigma Factor RpoS Is Critical for Its Activity.Frontiers in microbiology · 2017Article
- Article
- Stress-Induced Evolution of Heat Resistance and Resuscitation Speed in Escherichia coli O157:H7 ATCC 43888.Applied and environmental microbiology · 2016Article
- The General Stress Response Is Conserved in Long-Term Soil-Persistent Strains of Escherichia coli.Applied and environmental microbiology · 2016Article
- Fitness of Outbreak and Environmental Strains of Escherichia coli O157:H7 in Aerosolizable Soil and Association of Clonal Variation in Stress Gene Regulation.Pathogens (Basel, Switzerland) · 2014Article
- Selection for loss of RpoS in Cronobacter sakazakii by growth in the presence of acetate as a carbon source.Applied and environmental microbiology · 2013Article
- Polymorphisms in rpoS and stress tolerance heterogeneity in natural isolates of Cronobacter sakazakii.Applied and environmental microbiology · 2012Article
- Distinct transcriptional profiles and phenotypes exhibited by Escherichia coli O157:H7 isolates related to the 2006 spinach-associated outbreak.Applied and environmental microbiology · 2012Article
- The uncertain consequences of transferring bacterial strains between laboratories - rpoS instability as an example.BMC microbiology · 2011Article
- Phenotypic diversity caused by differential RpoS activity among environmental Escherichia coli isolates.Applied and environmental microbiology · 2011Article
- Evolution of the RpoS regulon: origin of RpoS and the conservation of RpoS-dependent regulation in bacteria.Journal of molecular evolution · 2010Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThough RpoS is important for survival of pathogenic Escherichia coli in natural environments, polymorphism in the rpoS gene is common. However, the causes of this polymorphism and consequential physiological effects on gene expression in pathogenic strains are not fully understood.
resultsIn this study, we found that growth on non-preferred carbon sources can efficiently select for loss of RpoS in seven of ten representative verocytotoxin-producing E. coli (VTEC) strains. Mutants (Suc++) forming large colonies on succinate were isolated at a frequency of 10-8 mutants per cell plated. Strain O157:H7 EDL933 yielded mainly mutants (about 90%) that were impaired in catalase expression, suggesting the loss of RpoS function. As expected, inactivating mutations in rpoS sequence were identified in these mutants. Expression of two pathogenicity-related phenotypes, cell adherence and RDAR (red dry and rough) morphotype, were also attenuated, indicating positive control by RpoS. For the other Suc++ mutants (10%) that were catalase positive, no mutation in rpoS was detected.
conclusionThe selection for loss of RpoS on poor carbon sources is also operant in most pathogenic strains, and thus is likely responsible for the occurrence of rpoS polymorphisms among E. coli isolates.
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