ArticleJournal of cellular biochemistry2009
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.
Article in Journal of cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Integrated analysis of genome-wide association studies and 3D epigenomic characteristics reveal the BMP2 gene regulating loin muscle depth in Yorkshire pigs.PLoS genetics · 2023Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages.Age (Dordrecht, Netherlands) · 2016Trial
- A Functional Variant Alters the Binding ofAnimals : an open access journal from MDPI · 2023Article
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Association BetweenAnimals : an open access journal from MDPI · 2020Article
- Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.Genesis (New York, N.Y. : 2000) · 2017Article
- Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.Journal of cellular biochemistry · 2016Article
- Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis.PloS one · 2016Article
- Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.Journal of cellular biochemistry · 2015Review
- Highlights from the functional single nucleotide polymorphisms associated with human muscle size and strength or FAMuSS study.BioMed research international · 2013Article
- The genetic pleiotropy of musculoskeletal aging.Frontiers in physiology · 2012Article
- An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heart.Genesis (New York, N.Y. : 2000) · 2011Article
- An autonomous BMP2 regulatory element in mesenchymal cells.Journal of cellular biochemistry · 2011Article
- CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Review
- Repressive BMP2 gene regulatory elements near the BMP2 promoter.Biochemical and biophysical research communications · 2010Article
Corrections and comments
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Authors and funding
19 authors at 12 institutions in 2 countries.
Funding
Abstract
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 inhibits myogenesis. Thus, BMP2 synthesis is tightly controlled. Several hundred nucleotides within the 3' untranslated regions of BMP2 genes are conserved from mammals to fishes indicating that the region is under stringent selective pressure. Our analyses indicate that this region controls BMP2 synthesis by post-transcriptional mechanisms. A common A to C single nucleotide polymorphism (SNP) in the BMP2 gene (rs15705, +A1123C) disrupts a putative post-transcriptional regulatory motif within the human ultra-conserved sequence. In vitro studies indicate that RNAs bearing the A or C alleles have different protein binding characteristics in extracts from mesenchymal cells. Reporter genes with the C allele of the ultra-conserved sequence were differentially expressed in mesenchymal cells. Finally, we analyzed MRI data from the upper arm of 517 healthy individuals aged 18-41 years. Individuals with the C/C genotype were associated with lower baseline subcutaneous fat volumes (P = 0.0030) and an increased gain in skeletal muscle volume (P = 0.0060) following resistance training in a cohort of young males. The rs15705 SNP explained 2-4% of inter-individual variability in the measured parameters. The rs15705 variant is one of the first genetic markers that may be exploited to facilitate early diagnosis, treatment, and/or prevention of diseases associated with poor fitness. Furthermore, understanding the mechanisms by which regulatory polymorphisms influence BMP2 synthesis will reveal novel pharmaceutical targets for these disabling conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.