ArticleNature structural & molecular biology2009
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].
Article in Nature structural & molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Uncovering supramolecular chirality codes for the design of tunable biomaterials.Nature communications · 2024Article
- Methionine Sulfoxide Reductases Suppress the Formation of the [Antioxidants (Basel, Switzerland) · 2023Article
- Trans-seeding of Alzheimer-related tau protein by a yeast prion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- A bacteria-based genetic assay detects prion formation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Enabling stop codon read-through translation in bacteria as a probe for amyloid aggregation.Scientific reports · 2017Article
- Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.The Journal of clinical investigation · 2017Article
- Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo.PLoS genetics · 2016Article
- A Decentralized Approach to the Formulation of Hypotheses: A Hierarchical Structural Model for a Prion Self-Assembled System.Scientific reports · 2016Article
- Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.Journal of molecular biology · 2016Review
- Mechanisms of amyloid formation revealed by solution NMR.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- Engineered bacterial hydrophobic oligopeptide repeats in a synthetic yeast prion, [REP-PSI (+)].Frontiers in microbiology · 2015Article
- Review
- Looked at life from both sides now.Life (Basel, Switzerland) · 2014Review
- Visualization of transient protein-protein interactions that promote or inhibit amyloid assembly.Molecular cell · 2014Article
- Article
- Ion-specific effects on prion nucleation and strain formation.The Journal of biological chemistry · 2013Article
- Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein.Biochemistry · 2013Article
- Cellular strategies for regulating functional and nonfunctional protein aggregation.Cell reports · 2012Article
- Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)].Chemistry & biology · 2012Article
- Prions in yeast.Genetics · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI(+)], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.