ArticleBritish journal of cancer2009
High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- GRP78 Protein Expression as Prognostic Values in Neoadjuvant Chemoradiotherapy and Laparoscopic Surgery for Locally Advanced Rectal Cancer.Cancer research and treatment · 2015Trial
- Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment.Annals of surgical oncology · 2011Trial
- Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review.Medical oncology (Northwood, London, England) · 2026Review
- Association between Ki67 expression and therapeutic outcome in colon cancer.Oncology letters · 2023Article
- Transcriptomic Analyses of Pretreatment Tumor Biopsy Samples, Response to Neoadjuvant Chemoradiotherapy, and Survival in Patients With Advanced Rectal Cancer.JAMA network open · 2023Article
- Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Predictive immunohistochemical features for tumour response to chemoradiotherapy in rectal cancer.BJS open · 2020Article
- Histogram parameters derived from T2 weighted images are associated with histopathological findings in rectal cancer - a preliminary study.American journal of translational research · 2018Article
- Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer.Radiation oncology (London, England) · 2017Article
- Observational
- The preoperative SUVmax for (18)F-FDG uptake predicts survival in patients with colorectal cancer.BMC cancer · 2015Article
- Predictive markers of chemoradiotherapy for rectal cancer: comparison of biopsy specimens taken before and about 1 week after the start of chemoradiotherapy.International journal of clinical oncology · 2015Article
- Association of beclin 1 expression with response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal carcinoma.International journal of cancer · 2015Article
- BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets.World journal of surgical oncology · 2015Article
- Gender-related differences in pathological and clinical tumor response based on immunohistochemical proteins expression in rectal cancer patients treated with short course of preoperative radiotherapy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
- P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer.BMC cancer · 2014Article
- Survivin expression can predict the effect of chemoradiotherapy for advanced lower rectal cancer.International journal of clinical oncology · 2013Article
- Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer.International journal of colorectal disease · 2013Article
- Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy.OncoTargets and therapy · 2013Article
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Abstract
backgroundRecently, preoperative chemoradiation therapy (CRT) for rectal cancer has been increasingly used as a neoadjuvant treatment. In the present study, the relation between histological response to CRT and immunohistochemical markers in biopsy specimens was investigated.
methodsBiopsy specimens from a total of 60 patients were collected before preoperative CRT with S-1 and irinotecan, and liniac 45 Gy. Immunohistochemical staining for Ki67, Mcm3, Bax, Bcl-2, ssDNA, Grp78, thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), CD34, vascular endothelial growth factor, nestin, and L-type amino-acid transporter 1 was performed to allow comparison of the Ki67 labelling index (LI), Bax score, TS score, DPD score, microvessel density by CD34, and Grp78 score with cancer regression.
resultsWhen the cases were divided into responders (Dworak grades 3 and 4) and non-responders (grades 1 and 2) groups, good correlations were evident with Ki67 LI, Bax, Grp78, and TS expression. On multiple logistic regression analysis, Ki67 LI, Bax, and TS scores were found to be independent factors. With their use in a logistic model, P-values could predict responder cases with a sensitivity of 82.8% and a specificity of 83.9%.
conclusionUsing this system, treatment strategy for locally advanced rectal cancers can be determined before chemoradiation.
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