Trial reportThe American journal of gastroenterology2009
Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia.
Trial report in The American journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus.The American journal of gastroenterology · 2016Guideline
- Buried metaplasia after endoscopic ablation of Barrett's esophagus: a systematic review.The American journal of gastroenterology · 2011Pooled it
- Durability of radiofrequency ablation in Barrett's esophagus with dysplasia.Gastroenterology · 2011Trial
- Biopsy depth after radiofrequency ablation of dysplastic Barrett's esophagus.Gastrointestinal endoscopy · 2010Trial
- Impact of post RFA treatment on neosquamous epithelium microstructure.Scientific reports · 2024Observational
- Standard versus simplified radiofrequency ablation protocol for Barrett's esophagus: comparative analysis of the whole treatment pathway.Endoscopy international open · 2020Article
- Radiofrequency Ablation for Early Superficial Flat Esophageal Squamous Cell Neoplasia: A Comprehensive Review.Gastroenterology research and practice · 2020Review
- Inflammatory bowel disease- and Barrett's esophagus-associated neoplasia: the old, the new, and the persistent struggles.Gastroenterology report · 2019Review
- MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus.World journal of gastroenterology · 2017Article
- Changes in gene expression of neo-squamous mucosa after endoscopic treatment for dysplastic Barrett's esophagus and intramucosal adenocarcinoma.United European gastroenterology journal · 2017Article
- Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography.Biomedical optics express · 2016Article
- Cleavage of E-Cadherin Contributes to Defective Barrier Function in Neosquamous Epithelium.Digestive diseases and sciences · 2016Article
- Post-ablation surveillance in Barrett's esophagus: A review of the literature.World journal of gastroenterology · 2016Review
- Update on management of Barrett's esophagus.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.The American journal of surgical pathology · 2016Review
- Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Review
- Radiofrequency ablation for Barrett's-associated intramucosal carcinoma: a multi-center follow-up study.Surgical endoscopy · 2014Article
- Article
- Endoscopic mucosal resection of Barrett's esophagus detects high prevalence of subsquamous intestinal metaplasia.World journal of gastrointestinal endoscopy · 2013Article
- Barrett's esophagus: review of diagnosis and treatment.Gastroenterology report · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEndoscopic radiofrequency ablation (RFA) eradicates intestinal metaplasia and intraepithelial neoplasia associated with Barrett's esophagus (BE), restoring an endoscopically normal neosquamous epithelium (NSE). We evaluated the post-RFA NSE for genetic abnormalities and buried glandular mucosa.
methodsEligible patients underwent RFA for BE containing early cancer and/or high-grade intraepithelial neoplasia with subsequent complete histological reversion to normal NSE. At baseline, the BE was sampled by brush cytology and biopsies. At least 2 months after RFA, the NSE was sampled by brush cytology, keyhole biopsies, and endoscopic resection. The untreated squamous epithelium was biopsied as a control. The baseline BE and post-RFA NSE were evaluated for immunohistochemical expression of Ki-67 and p53, and genetic abnormalities (DNA-fluorescent in situ hybridization: chromosome 1 and 9, p16 and p53). In addition, biopsy depth was compared for biopsies from the NSE and untreated squamous epithelium. The presence of buried glandular mucosa in NSE was assessed with primary and keyhole biopsy, and endoscopic resection.
resultsAll pretreatment specimens from all 22 patients showed abnormalities on immunohistochemical staining and fluorescent in situ hybridization, whereas all post-RFA NSE specimens were normal. All the post-RFA biopsies from the NSE contained full epithelia, whereas 37% contained lamina propria, a finding no different from biopsies from untreated squamous epithelium (36% lamina propria). Deeper keyhole biopsies contained lamina propria in 51%. All endoscopic resection specimens contained submucosa, whereas no biopsy or endoscopic resection specimen contained buried glandular mucosa.
conclusionsRigorous evaluation of the post-RFA NSE in patients who, at baseline, had BE containing early cancer high-grade intraepithelial neoplasia, showed neither persistent genetic abnormalities nor buried glandular mucosa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.