ArticleJournal of carcinogenesis2009
Protein expression analysis of inflammation-related colon carcinogenesis.
Article in Journal of carcinogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Moderate NADH supplementation prevents early colon carcinogenesis by modulating inflammation and oxidative stress in a mouse model.Journal of molecular histology · 2025Article
- Animal models of inflammatory bowel disease: novel experiments for revealing pathogenesis of colitis, fibrosis, and colitis-associated colon cancer.Intestinal research · 2023Review
- Assessment of the Anti-Cancer Efficiency of Silver Moringa oleifera Leaves Nano-extract against Colon Cancer Induced Chemically in Rats.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- IgG Fc Binding Protein (OncoTargets and therapy · 2021Article
- Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate improperly mimic human colorectal cancer.Scientific reports · 2017Article
- FcGBP was upregulated by HPV infection and correlated to longer survival time of HNSCC patients.Oncotarget · 2017Article
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- Fcgbp - A Potential Viral Trap in RV144.The open AIDS journal · 2014Article
- Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma.Cancer research · 2013Article
- The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin.Stem cells (Dayton, Ohio) · 2012Article
- Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice.BMC medical genomics · 2012Article
- Preclinical cancer chemoprevention studies using animal model of inflammation-associated colorectal carcinogenesis.Cancers · 2012Article
- Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention.International journal of inflammation · 2012Article
- Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects.PloS one · 2012Article
- Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells.Journal of clinical biochemistry and nutrition · 2012Article
- Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.Journal of biomedicine & biotechnology · 2012Review
- Identification of α(1,6)fucosylated proteins differentially expressed in human colorectal cancer.BMC cancer · 2011Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation is a risk factor for colorectal cancer (CRC) development. The aim of this study was to determine the differences in protein expression between CRC and the surrounding nontumorous colonic tissues in the mice that received azoxymethane (AOM) and dextran sodium sulfate (DSS) using a proteomic analysis. MATERIALS AND
methodsMale ICR mice were given a single intraperitoneal injection of AOM (10 mg/kg body weight), followed by 2% (w/v) DSS in their drinking water for seven days, starting one week after the AOM injection. Colonic adenocarcinoma developed after 20 weeks and a proteomics analysis based on two-dimensional gel electrophoresis and ultraflex TOF/TOF mass spectrometry was conducted in the cancerous and nontumorous tissue specimens.
resultsThe proteomic analysis revealed 21 differentially expressed proteins in the cancerous tissues in comparison to the nontumorous tissues. There were five markedly increased proteins (beta-tropomyosin, tropomyosin 1 alpha isoform b, S100 calcium binding protein A9, and an unknown protein) and 16 markedly decreased proteins (Car1 proteins, selenium-binding protein 1, HMG-CoA synthase, thioredoxin 1, 1 Cys peroxiredoxin protein 2, Fcgbp protein, Cytochrome c oxidase, subunit Va, ETHE1 protein, and 7 unknown proteins).
conclusionsThere were 21 differentially expressed proteins in the cancerous tissues of the mice that received AOM and DSS. Their functions include metabolism, the antioxidant system, oxidative stress, mucin production, and inflammation. These findings may provide new insights into the mechanisms of inflammation-related colon carcinogenesis and the establishment of novel therapies and preventative strategies to treat carcinogenesis in the inflamed colon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.