ArticleExperimental biology and medicine (Maywood, N.J.)2009
Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma.
Article in Experimental biology and medicine (Maywood, N.J.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging.Biomedicines · 2021Article
- Influence of Sex on Neuroretinal Degeneration: Six-Month Follow-Up in Rats With Chronic Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Discovery and clinical translation of novel glaucoma biomarkers.Progress in retinal and eye research · 2021Review
- Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model.Investigative ophthalmology & visual science · 2020Article
- Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice.Scientific reports · 2019Article
- Molecular Biomarkers for Glaucoma.Current ophthalmology reports · 2019Article
- Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications.Trends in molecular medicine · 2018Review
- Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork.Experimental eye research · 2015Review
- Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure.Experimental eye research · 2015Review
- Differential gene expression in glaucoma.Cold Spring Harbor perspectives in medicine · 2014Review
- Solving the lost in translation problem: improving the effectiveness of translational research.Current opinion in pharmacology · 2013Review
- Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma.Experimental eye research · 2011Review
- Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma model.Investigative ophthalmology & visual science · 2011Article
- Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes.Current eye research · 2010Article
- Global gene expression changes in rat retinal ganglion cells in experimental glaucoma.Investigative ophthalmology & visual science · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Glaucoma is a group of genetically heterogeneous neurodegenerative disorders causing the degeneration of the ganglion neurons of the retina. Increased intraocular pressure (IOP) is a hallmark risk factor promoting the death of ganglion neurons of the retina in glaucoma. Yet, the molecular processes underlying the degeneration of these neurons by increased IOP are not understood. To gain insight into the early molecular events and discover biomarkers induced by IOP, we performed gene and protein expression profiling to compare retinas of eyes with and without high IOP in a rodent model of experimental glaucoma. This pilot study found that the IOP-mediated changes in the transcription levels of a restricted set of genes implicated in peroxisomal and mitochondrial function, modulation of neuron survival and inflammatory processes, were also accompanied by changes in the levels of proteins encoded by the same genes. With the exception of the inflammatory markers, serum amyloid-A1 (SAA1) and serum amyloid-A2 (SAA2), the IOP-induced changes in protein expression were restricted to ganglion neurons of the retina and they were detected also in the vitreous, thus suggesting an early IOP-mediated loss of ganglion cell integrity. Interestingly, SAA1 and SAA2 were induced in retinal microglia cells, whereas they were reduced in sera of IOP-responsive mice. Hence, this study defines novel IOP-induced molecular processes, biomarkers and sources thereof, and it further validates the extension of the analyses herein reported to other genes modulated by IOP.
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Registered trials
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