Evidence map›Paper›PMID 19491064›Full record

SynthesisEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials.

Alexandra V Yamshchikov, Nirali S Desai, Henry M Blumberg, Thomas R Ziegler, Vin Tangpricha

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02047799 (Effect of Vitamin D Supplementation on Blood Pressure in Elderly People), which is not on this map. Cited by 129 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 9 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02047799 phase2completednot on this map

Effect of Vitamin D Supplementation on Blood Pressure in Elderly People

TypeinterventionalSponsorUniversidad de ColimaRan2013 to 2013Enrolled45ConditionsHigh Blood PressureArmsCalcitriol, Control
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 9 syntheses or guidelines pooled it, 320 citations in OpenAlex.

  1. Pooled it
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  7. Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010
    Guideline
  8. Pooled it
  9. Immunostimulants for preventing respiratory tract infection in children.The Cochrane database of systematic reviews · 2006
    Pooled it
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  18. Review
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexandra V YamshchikovDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30030, USA. AYAMSHC@emory.edu
Nirali S Desai
Henry M Blumberg
Thomas R Ziegler
Vin Tangpricha
Emory University · USOffice of Infectious Diseases · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
ENDOCRINOLOGY, METABOLISM, AND DIABETEST32DK007298 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 1986 to 2014
$3.2M
Patient Oriented Research in Clinical NutritionK24RR023356 · NCRR · EMORY UNIVERSITY · PI ZIEGLER, THOMAS R · 2007 to 2011
$839k
Role of T-cells in Osteoporosis in Women Undergoing Surgical MenopauseK23AR054334 · NIAMS · EMORY UNIVERSITY · PI TANGPRICHA, VIN · 2007 to 2011
$641k
NCATS NIH HHS UL1 TR000454NCRR NIH HHS K24 RR023356NIAMS NIH HHS K23 AR054334NIDDK NIH HHS T32 DK007298NIDDK NIH HHS T32DK007298
6 · The paper itself

Abstract

objectiveTo review the existing human controlled intervention studies of vitamin D as adjunctive therapy in settings of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence reviewed.

methodsWe conducted a systematic review of randomized controlled clinical trials that studied vitamin D for treatment or prevention of infectious diseases in humans. Studies from 1948 through 2009 were identified through search terms in PubMed and Ovid MEDLINE.

resultsThirteen published controlled trials were identified by our search criteria. Ten trials were placebo controlled, and 9 of the 10 were conducted in a rigorous double-blind design. The selected clinical trials demonstrated substantial heterogeneity in baseline patient demographics, sample size, and vitamin D intervention strategies. Serious adverse events attributable to vitamin D supplementation were rare across all studies. On the basis of studies reviewed to date, the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis, influenza, and viral upper respiratory tract illnesses. In the selected studies, certain aspects of study design are highlighted to help guide future clinical research in the field.

conclusionMore rigorously designed clinical trials are needed for further evaluation of the relationship between vitamin D status and the immune response to infection as well as for delineation of necessary changes in clinical practice and medical care of patients with vitamin D deficiency in infectious disease settings.

Indexed as

Communicable DiseasesHumansRandomized Controlled Trials as TopicVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID19491064
PMCPMC2855046
OpenAlexW2055395401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.