ReviewInternational review of cell and molecular biology2009
Viral channel-forming proteins.
Review in International review of cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Functional RNA Elements in Alphavirus Genomes.Current microbiology · 2025Review
- Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress.Viruses · 2019Article
- Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics.The Journal of cell biology · 2018Article
- Review
- Membrane protein assembly: two cytoplasmic phosphorylated serine sites of Vpu from HIV-1 affect oligomerization.Scientific reports · 2016Article
- Structure based computational assessment of channel properties of assembled ORF-8a from SARS-CoV.Proteins · 2015Article
- The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production.Biochimica et biophysica acta · 2014Article
- Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs.SpringerPlus · 2013Article
- Viroporins: structure and biological functions.Nature reviews. Microbiology · 2012Review
- In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV.Journal of molecular modeling · 2012Article
- Mechanism of function of viral channel proteins and implications for drug development.International review of cell and molecular biology · 2012Review
- The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels.PLoS computational biology · 2012Article
- Background K(2P) channels KCNK3/9/15 limit the budding of cell membrane-derived vesicles.Cell biochemistry and biophysics · 2011Article
- DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71.Cell research · 2011Article
- ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.Biochimica et biophysica acta · 2011Article
- Viral channel forming proteins - modeling the target.Biochimica et biophysica acta · 2011Review
- Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.PloS one · 2011Article
- Ion channels as antivirus targets.Virologica Sinica · 2010Review
- Structural implications of mutations assessed by molecular dynamics: Vpu1-32 from HIV-1.European biophysics journal : EBJ · 2010Article
- Modulating the activity of the channel-forming segment of Vpr protein from HIV-1.European biophysics journal : EBJ · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Channel-forming proteins are found in a number of viral genomes. In some cases, their role in the viral life cycle is well understood, in some cases it needs still to be elucidated. A common theme is that their mode of action involves a change of electrochemical or proton gradient across the lipid membrane which modulates the viral or cellular activity. Blocking these proteins can be a suitable therapeutic strategy as for some viruses this may be "lethal." Besides the many biological relevant questions still to be answered, there are also many open questions concerning the biophysical side as well as structural information and the mechanism of function on a molecular level. The immanent biophysical issues are addressed and the work in the field is summarized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.