ArticleReproductive toxicology (Elmsford, N.Y.)2009
TCDD exposure disrupts mammary epithelial cell differentiation and function.
Article in Reproductive toxicology (Elmsford, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia.Biochemistry and biophysics reports · 2024Article
- Unique challenges and best practices for single cell transcriptomic analysis in toxicology.Current opinion in toxicology · 2024Article
- Genome-Wide Signal Selection Analysis Revealing Genes Potentially Related to Sheep-Milk-Production Traits.Animals : an open access journal from MDPI · 2023Article
- Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer.International journal of molecular sciences · 2020Review
- Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice.Journal of proteome research · 2018Article
- Maternal Resveratrol Treatment Reduces the Risk of Mammary Carcinogenesis in Female Offspring Prenatally Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.Hormones & cancer · 2017Article
- Carcinogenetic mechanisms of endocrine disruptors in female cancers (Review).Oncology reports · 2016Review
- Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling.Environmental health perspectives · 2016Article
- Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.Bioorganic & medicinal chemistry letters · 2014Article
- Imprinting genes associated with endometriosis.EXCLI journal · 2014Review
- Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Role of the Arylhydrocarbon Receptor (AhR) in the Pathology of Asthma and COPD.Journal of allergy · 2012Article
- Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues.Biology of reproduction · 2011Article
- Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors.International journal of cancer · 2011Article
- Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Stem cells and development · 2011Article
- Chemical exposure as etiology in developmental origin of adult onset human cancer.Frontiers in pharmacology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mammary gland growth and differentiation during pregnancy is a developmental process that is sensitive to the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a widespread environmental contaminant and a potent ligand for the aryl hydrocarbon receptor (AhR). We demonstrate reduced beta-casein protein induction in mouse mammary glands and in cultured SCp2 mammary epithelial cells following exposure to TCDD. SCp2 cells exposed to TCDD also show reduced cell clustering and less alveolar-like structure formation. SCp2 cells express transcriptionally active AhR, and exposure to TCDD induces expression of the AhR target gene CYP1B1. Exposure to TCDD during pregnancy reduced expression of the cell adhesion molecule E-cadherin in the mammary gland and decreased phosphorylation of STAT5, a known regulator of beta-casein gene expression. These data provide morphological and molecular evidence that TCDD-mediated AhR activation disrupts structural and functional differentiation of the mammary gland, and present an in vitro model for studying the effects of TCDD on mammary epithelial cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.