ArticleCell metabolism2009
mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription.
Article in Cell metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 103 citations in OpenAlex.
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- iTRAQ-Based Proteomic Analysis of Dentate Gyrus in Temporal Lobe Epilepsy With Hippocampal Sclerosis.Frontiers in neurology · 2020Article
- Genome-Wide Identification and Characterization of the Mitochondrial Transcription Termination Factors (mTERFs) inInternational journal of molecular sciences · 2019Article
- Prognostic roles of mitochondrial transcription termination factors in non-small cell lung cancer.Oncology letters · 2019Article
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- A Member of the Arabidopsis Mitochondrial Transcription Termination Factor Family Is Required for Maturation of Chloroplast Transfer RNAIle(GAU).Plant physiology · 2015Article
- Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Mitochondrion · 2015Review
- MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.Human molecular genetics · 2015Article
- Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.Human molecular genetics · 2014Article
- NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly.PLoS genetics · 2014Article
- AAV-mediated liver-specific MPV17 expression restores mtDNA levels and prevents diet-induced liver failure.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Arabidopsis mTERF15 is required for mitochondrial nad2 intron 3 splicing and functional complex I activity.PloS one · 2014Article
- Genome-wide identification, evolution and expression analysis of mTERF gene family in maize.PloS one · 2014Article
- The mTERF protein MOC1 terminates mitochondrial DNA transcription in the unicellular green alga Chlamydomonas reinhardtii.Nucleic acids research · 2013Article
- Accessorizing the human mitochondrial transcription machinery.Trends in biochemical sciences · 2013Review
- Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.Nucleic acids research · 2013Article
Corrections and comments
- Retraction · 2015-10-06Duplication of/in Image · Euphemisms for Duplication · Investigation by Company/Institution · Investigation by Journal/Publisher · Legal Reasons and/or Threats · · See also T Wenz entries with T Wenz named for misconduct;
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of mitochondrial protein expression is crucial for the function of the oxidative phosphorylation (OXPHOS) system. Although the basal machinery for mitochondrial transcription is known, the regulatory mechanisms are not completely understood. Here, we characterized mTERF2, a mitochondria-localized homolog of the mitochondrial transcription termination factor mTERF1. We show that inactivation of mTERF2 in the mouse results in a myopathy and memory deficits associated with decreased levels of mitochondrial transcripts and imbalanced tRNA pool. These aberrations were associated with decreased steady-state levels of OXPHOS proteins causing a decrease in respiratory function. mTERF2 binds to the mtDNA promoter region, suggesting that it affects transcription initiation. In vitro interaction studies suggest that mtDNA mediates interactions between mTERF2 and mTERF3. Our results indicate that mTERF1, mTERF2, and mTERF3 regulate transcription by acting in the same site in the mtDNA promoter region and thereby mediate fine-tuning of mitochondrial transcription and hence OXPHOS function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.