Evidence map›Paper›PMID 19490612›Full record

ArticleBMC research notes2009

Norovirus infections in preterm infants: wide variety of clinical courses.

Sven Armbrust, Axel Kramer, Dirk Olbertz, Kathrin Zimmermann, Christoph Fusch

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. S2k-Guideline hand antisepsis and hand hygiene.GMS hygiene and infection control · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Norovirus.Clinical microbiology reviews · 2015
    Review
  7. Pediatric norovirus infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Article
  8. Article
  9. Norovirus genogroup II gastroenteritis in hospitalized children in South India.The American journal of tropical medicine and hygiene · 2013
    Article
  10. Review
  11. Article
  12. Norovirus gastroenteritis in immunocompromised patients.The New England journal of medicine · 2013
    Article
  13. Norovirus gastroenteritis in immunocompromised patients.The New England journal of medicine · 2012
    Review
  14. Article
  15. Clinical characteristics of viral intestinal infection in preterm and term neonates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sven ArmbrustDepartment of Neonatology, University-Children's Hospital, 17475 Greifswald, Germany. sven.armbrust@web.de
Axel Kramer
Dirk Olbertz
Kathrin Zimmermann
Christoph Fusch
Universitätsmedizin Greifswald · DEFriedrich-Loeffler-Institut · DEUniversität Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNorovirus is an important cause of nonbacterial acute gastroenteritis in all ages. Atypical courses are described. Clinical symptoms are diarrhea, vomiting, nausea, abdominal cramps, fever and malaise. Apart from three recent short reports we describe for the first time an outbreak of norovirus in a tertiary Neonatal Intensive Care Unit.

findingsThe typical symptoms of norovirus infection are in part also seen in premature born infants but with a different pattern and a huge variety of clinical courses. Vomiting is not the main symptom of norovirus infection in premature infants but distended abdomen and other symptoms such as apnea, gastric remainders or sepsis like appearance. The course in premature born patients could be explained by an immunocompromised mice model. Extensive hygienic measures were necessary to control the outbreak without closing the Neonatal Intensive Care Unit.

conclusionNorovirus infection in premature infants shows an impressive pattern of a wide variety of clinical courses. Only the consequent use of different hygienic pattern can lead to elimination of norovirus.

Identifiers

PMID19490612
PMCPMC2695820
OpenAlexW2078586703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.