ArticleGenome biology2009
Closing gaps in the human genome using sequencing by synthesis.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Tracing the evolution of sequencing into the era of genomic medicine.Nature reviews. Genetics · 2025Review
- Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.Molecular cell · 2019Article
- Article
- The Fluid Mechanics of Genome Mapping.AIChE journal. American Institute of Chemical Engineers · 2013Article
- Sequence and expression analysis of gaps in human chromosome 20.Nucleic acids research · 2012Article
- Article
- Replacement of the myotonic dystrophy type 1 CTG repeat with 'non-CTG repeat' insertions in specific tissues.Journal of medical genetics · 2011Article
- The development and characterization of a 60K SNP chip for chicken.BMC genomics · 2011Article
- A vertebrate case study of the quality of assemblies derived from next-generation sequences.Genome biology · 2011Article
- Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries.Genome biology · 2011Article
- Are we Genomic Mosaics? Variations of the Genome of Somatic Cells can Contribute to Diversify our Phenotypes.Current genomics · 2010Article
- SNP identification, verification, and utility for population genetics in a non-model genus.BMC genetics · 2010Article
- Linear plasmid vector for cloning of repetitive or unstable sequences in Escherichia coli.Nucleic acids research · 2010Article
- Human genomics: The genome finishers.Nature · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.