ReviewArthritis research & therapy2009
The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.
Review in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence.Oxidative medicine and cellular longevity · 2020Pooled it
- An integrative transcriptome analysis framework for drug efficacy and similarity reveals drug-specific signatures of anti-TNF treatment in a mouse model of inflammatory polyarthritis.PLoS computational biology · 2019Article
- Special issue: global 3Rs efforts - making progress and gaining momentum.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.Frontiers in cellular and infection microbiology · 2014Review
- Genetics of rheumatoid arthritis - a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.Clinical & developmental immunology · 2012Review
- Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.Arthritis and rheumatism · 2011Article
- Characterization of a novel and spontaneous mouse model of inflammatory arthritis.Arthritis research & therapy · 2011Article
- Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.Arthritis and rheumatism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.
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Registered trials
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