ArticleEuropean journal of clinical investigation2009
Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia.
Article in European journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01255644 (Treatment of Chronic Lymphocytic Leukemia With the Use of an Antiviral Compound - a Proof of Principle Study), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Chronic Lymphocytic Leukemia With the Use of an Antiviral Compound - a Proof of Principle Study
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Beyond the Usual Suspects: Emerging Associations Between Epstein-Barr Virus Infection/Infectious Mononucleosis and Cancers.Reviews in medical virology · 2026Review
- Human herpesvirus 7 and the risk of developing multiple sclerosis.Brain communications · 2026Article
- TheFrontiers in immunology · 2021Article
- Does microbiome shift play a role in carcinogenesis? A systematic review.Translational cancer research · 2020Review
- Engineering extracellular vesicles as novel treatment options: exploiting herpesviral immunity in CLL.Journal of extracellular vesicles · 2019Article
- Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.Frontiers in immunology · 2019Article
- Human Herpesvirus 6 and Malignancy: A Review.Frontiers in oncology · 2018Review
- Lymphoproliferative Syndromes Associated with Human Herpesvirus-6A and Human Herpesvirus-6B.Mediterranean journal of hematology and infectious diseases · 2018Review
- Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens.EMBO molecular medicine · 2017Article
- Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia.Jundishapur journal of microbiology · 2015Article
- The pathogenesis of chronic lymphocytic leukemia.Annual review of pathology · 2014Review
- Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.Cancer immunology, immunotherapy : CII · 2013Article
- Mechanistic insights into the impairment of memory B cells and antibody production in the elderly.Age (Dordrecht, Netherlands) · 2013Article
- Article
- Immunoglobulin gene repertoire in chronic lymphocytic leukemia: insight into antigen selection and microenvironmental interactions.Mediterranean journal of hematology and infectious diseases · 2012Article
- β-HHVs and HHV-8 in Lymphoproliferative Disorders.Mediterranean journal of hematology and infectious diseases · 2011Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHerpes virus infections may have a significant role in chronic lymphocytic leukaemia (CLL) due to their ability to modulate the host's immune system. MATERIALS AND
methodsWe examined the seroprevalence of four herpes viruses [Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), human herpes virus (HHV)-6 and -7] in a cohort of European CLL patients (cohort 1, n = 100) in relation to the immunoglobulin variable heavy (IGHV) chain gene use and compared serological results with those obtained from age- and gender-matched healthy adults (n = 100).
resultsCMV-seroprevalence was significantly higher in CLL cohort 1 (79%) than in the control cohort (57%, P = 0.001); the seroprevalence of EBV (89% vs. 94%), HHV-6 (73% vs. 60%), or HHV-7 (35% vs. 35%) was not. In CLL cohort 1, use of IGHV3-30 was more prevalent among CMV-seropositive and of IGHV3-21 among HHV-7-seronegative cases. To investigate the generalizability of these findings, we investigated the herpes virus seroprevalence in a second cohort of age-matched CLL patients from a different geographical area (USA, n = 100, cohort 2). In cohort 2, CMV-seroprevalence was comparable with that of the control cohort (53%). Seroprevalence of EBV, HHV-6 and HHV-7 were 85%, 88% and 73% respectively. In CLL cohort 2, use of IGHV3-30 or IGHV3-21 was not associated with any of the herpes viruses investigated.
conclusionsCMV-seropositivity is associated with CLL in selected patient cohorts. However, the considerable variation in herpes virus-specific seropositivity between geographically distinct CLL cohorts indicates that seropositivity for any of the four human herpes viruses investigated is not generally associated with CLL.
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