ArticleEpilepsia2009
Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy.
Article in Epilepsia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- A systematic review of resting-state and task-based fmri in juvenile myoclonic epilepsy.Brain imaging and behavior · 2022Pooled it
- Gray Matter Changes in Juvenile Myoclonic Epilepsy. A Voxel-Wise Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies.PloS one · 2017Pooled it
- Gray matter density alterations in idiopathic generalized epilepsy patients: a double inversion recovery Magnetic Resonance Imaging study.Acta epileptologica · 2026Article
- Transcriptional and neurotransmitter signatures associated with regional gray matter alterations in juvenile myoclonic epilepsy.Frontiers in molecular neuroscience · 2026Article
- Enhanced response inhibition in patients with drug-resistant juvenile myoclonic epilepsy: Event-related potentials evidence of excitatory-inhibitory imbalance.Epilepsia open · 2025Article
- Abnormal gait and motor cortical processing in drug-resistant juvenile myoclonic epilepsy.Brain and behavior · 2023Article
- Digital Neuropsychological Assessment of Cognitive Functions in Patients with Epilepsy.Noro psikiyatri arsivi · 2023Article
- Development and Validation of MRI-Based Radiomics Models for Diagnosing Juvenile Myoclonic Epilepsy.Korean journal of radiology · 2022Article
- Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice.British journal of pharmacology · 2020Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings.Brain : a journal of neurology · 2019Observational
- Subtle Brain Developmental Abnormalities in the Pathogenesis of Juvenile Myoclonic Epilepsy.Frontiers in cellular neuroscience · 2019Review
- Reduced resilience of brain gray matter networks in idiopathic generalized epilepsy: A graph-theoretical analysis.PloS one · 2019Article
- Grey and White Matter Alterations in Juvenile Myoclonic Epilepsy: A Comprehensive Review.Journal of epilepsy research · 2017Review
- Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes.Korean journal of pediatrics · 2016Review
- Association of Family History of Epilepsy with Earlier Age Onset of Juvenile Myoclonic Epilepsy.Iranian journal of child neurology · 2016Article
- What graph theory actually tells us about resting state interictal MEG epileptic activity.NeuroImage. Clinical · 2015Article
- Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy.Acta neurologica Scandinavica · 2014Article
- Sex-specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy.Genes, brain, and behavior · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies using advanced imaging techniques have suggested subtle structural and functional changes in patients with juvenile myoclonic epilepsy (JME), mainly associated with the frontal lobes. In addition, it has been reported that these patients show neuropsychological deficits, often summarized as frontal lobe dysfunction. The aim of this study was a comprehensive analysis of neuropsychological parameters, and functional and structural magnetic resonance imaging (MRI) in an independent cohort of patients with JME.
methodsWe studied 19 JME patients and 20 age-, sex-, and education-matched controls using a battery of standardized neuropsychological tests, optimized voxel-based morphometry (VBM), and two domain-specific working-memory paradigms combined with functional MRI (fMRI).
resultsOur investigations did not reveal statistically significant differences between the groups of JME patients and normal controls in either the VBM or the fMRI study of working memory. The neuropsychological examination showed a slightly worse performance for the JME patients across most tests used, reaching statistical significance for semantic and verbal fluency.
conclusionsIn our cohort of JME patients, we could not reproduce the findings of frontal gray matter changes from previous studies, and we could not detect an fMRI correlate of previously reported differences in working memory in JME. The neuropsychological deficits may be attributed partially to antiepileptic medication. We conclude that structural and functional frontal lobe deficits in JME patients have to be interpreted with care. One reason for a variation between different cohorts may be the genetic heterogeneity of the disease.
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