ArticleThe journal of physical chemistry. B2009
Hydration number, topological control, and ion selectivity.
Article in The journal of physical chemistry. B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The Role of Architectural Forces in Ion Selectivity.Advances in experimental medicine and biology · 2026Article
- Polarization Effects in Water-Mediated Selective Cation Transport across a Narrow Transmembrane Channel.Journal of chemical theory and computation · 2021Article
- Direct measurement of the Mn(II) hydration state in metal complexes and metalloproteins through 17O NMR line widths.Journal of the American Chemical Society · 2013Article
- An entropic mechanism of generating selective ion binding in macromolecules.PLoS computational biology · 2013Article
- Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT.Biophysical journal · 2012Article
- Ionizable side chains at catalytic active sites of enzymes.European biophysics journal : EBJ · 2012Article
- Structural correlates of selectivity and inactivation in potassium channels.Biochimica et biophysica acta · 2012Review
- Probing the thermodynamics of competitive ion binding using minimum energy structures.The journal of physical chemistry. B · 2011Article
- Perspectives on: ion selectivity: design principles for K+ selectivity in membrane transport.The Journal of general physiology · 2011Article
- Ion selectivity in channels and transporters.The Journal of general physiology · 2011Review
- Mapping the importance of four factors in creating monovalent ion selectivity in biological molecules.Biophysical journal · 2011Article
- Two mechanisms of ion selectivity in protein binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Multibody effects in ion binding and selectivity.Biophysical journal · 2010Article
- Dehydration and ionic conductance quantization in nanopores.Journal of physics. Condensed matter : an Institute of Physics journal · 2010Article
- Selective complexation of K+ and Na+ in simple polarizable ion-ligating systems.Journal of the American Chemical Society · 2010Article
- A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide.Journal of the American Chemical Society · 2010Article
- Assessing the accuracy of approximate treatments of ion hydration based on primitive quasichemical theory.The Journal of chemical physics · 2010Article
- Exploring the ion selectivity properties of a large number of simplified binding site models.Biophysical journal · 2010Article
- Coordination numbers of K(+) and Na(+) Ions inside the selectivity filter of the KcsA potassium channel: insights from first principles molecular dynamics.Biophysical journal · 2010Article
- Ion selectivity from local configurations of ligands in solutions and ion channels.Chemical physics letters · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The topological control hypothesis presented by Bostick and Brooks [Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 9260] has sought to explain binding selectivity in potassium channels based on the premise that a universal measure of ion solvation in different environments is provided by its average coordination structure in bulk water. This leads to the view that ion selectivity is predominantly controlled by the number of ligands coordinating the ion and that the chemical type of those ligands plays a minor role. The significance of the topological control hypothesis and its ability to predict ion selectivity in protein binding sites are examined. It is shown that the framework encounters increasing difficulties when different protein binding sites with similar coordination numbers are considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.