ArticleJournal of computational neuroscience2009
Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents.
Article in Journal of computational neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Enhancement of calcium responses by KJournal of biosciences · 2026Article
- Dopamine Receptor 1 Specific CRISPRa Mice Exhibit Disrupted Behaviors and Striatal Baseline Cellular Activity.eNeuro · 2025Article
- Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity.bioRxiv : the preprint server for biology · 2025Article
- Synaptic Plasticity Is Predicted by Spatiotemporal Firing Rate Patterns and Robust to In Vivo-like Variability.Biomolecules · 2022Article
- Life extension factor klotho regulates behavioral responses to stress via modulation of GluN2B function in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Article
- Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.PLoS computational biology · 2021Article
- Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice.Molecular psychiatry · 2021Article
- Modeling nucleus accumbens : A Computational Model from Single Cell to Circuit Level.Journal of computational neuroscience · 2021Article
- Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons.Neuron · 2020Article
- Alternative classifications of neurons based on physiological properties and synaptic responses, a computational study.Scientific reports · 2019Article
- A computational model of large conductance voltage and calcium activated potassium channels: implications for calcium dynamics and electrophysiology in detrusor smooth muscle cells.Journal of computational neuroscience · 2019Article
- Article
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- Effects of location and extent of spine clustering on synaptic integration in striatal medium spiny neurons-a computational study.Medical & biological engineering & computing · 2018Article
- Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons.The European journal of neuroscience · 2017Article
- The Effects of Medium Spiny Neuron Morphologcial Changes on Basal Ganglia Network under External Electric Field: A Computational Modeling Study.Frontiers in computational neuroscience · 2017Article
- Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates.Journal of neurophysiology · 2013Article
- The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease.Frontiers in computational neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inward rectifying potassium (K(IR)) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in approximately 40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that K(IR) current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. These effects may be attributed to the higher input resistance of the cell as well as a more depolarized resting/down-state potential induced by the inactivation of this current. In view of the reports that dendritic intracellular calcium levels depend closely on burst strength and spike onset time, our findings suggest that inactivation of K(IR) currents may offer a means of modulating both excitability and synaptic plasticity in MS neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.