ArticleClinics (Sao Paulo, Brazil)2009
Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects.
Article in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The effects of alcohol consumption on flow-mediated dilation in humans: A systematic review.Physiological reports · 2021Pooled it
- Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials.PloS one · 2015Pooled it
- The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.PloS one · 2013Pooled it
- Morning sympathetic activity after evening binge alcohol consumption.American journal of physiology. Heart and circulatory physiology · 2021Trial
- Repeated ethanol exposure in female rats impairs cerebral endothelial function and increases cerebrovascular stiffness.European journal of pharmacology · 2026Article
- Polygenic Risk, Modifiable Lifestyle Behaviors, and Metabolic Factors: Associations with HDL-C, Triglyceride Levels, and Cardiovascular Risk.Nutrients · 2025Article
- Alcohol Consumption: A New Risk Factor for Arterial Stiffness?Cardiovascular toxicology · 2022Review
- Endothelium-Independent Relaxation of Vascular Smooth Muscle Induced by Persimmon-Derived Polyphenol Phytocomplex in Rats.Nutrients · 2021Article
- From bench to bar side: Evaluating theOpen life sciences · 2021Article
- Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits.Nutrition and metabolic insights · 2016Review
- Endothelium and its alterations in cardiovascular diseases: life style intervention.BioMed research international · 2014Review
- Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults.Nutrition research and practice · 2012Article
- The characteristics of stress cardiomyopathy in an ethnically heterogeneous population.Clinics (Sao Paulo, Brazil) · 2011Article
- Review
- Red wine: A drink to your heart.Journal of cardiovascular disease research · 2010Article
- ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats.Clinics (Sao Paulo, Brazil) · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the metabolic, hemodynamic, autonomic, and endothelial responses to short-term red wine consumption in subjects with hypercholesterolemia or arterial hypertension, and healthy controls.
methodsSubjects with hypercholesterolemia (n=10) or arterial hypertension (n=9), or healthy controls (n=7) were given red wine (250 mL/night) for 15 days. Analyses were performed before and after red wine intake.
resultsRed wine significantly increased the plasma levels of HDL-cholesterol in the controls, but not in the other groups. The effects on hemodynamic measurements were mild, non-significantly more prominent in healthy subjects, and exhibited high interindividual variability. Across all participants, mean blood pressure decreased 7 mmHg (p <0.01) and systemic vascular resistance decreased 7% (p = 0.05). Heart rate and cardiac output did not significantly change in any group. Red wine enhanced muscle sympathetic fibular nerve activity in hypercholesterolemic and hypertensive patients, but not in controls. At baseline, brachial artery flow-mediated dilation was impaired in patients with hypercholesterolemia and arterial hypertension; red wine restored the dilation in the hypercholesterolemic group but not in the hypertensive group.
conclusionsRed wine elicits different metabolic, autonomic, and endothelial responses among individuals with hypercholesterolemia or arterial hypertension and healthy controls. Our findings highlight the need to consider patient characteristics when evaluating the response to red wine.
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Registered trials
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