ArticleClinics (Sao Paulo, Brazil)2009
Persistent high postoperative carcinoembryonic antigen in colorectal cancer patients--is it important?
Article in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Blood CEA levels for detecting recurrent colorectal cancer.The Cochrane database of systematic reviews · 2015Pooled it
- A randomized controlled trial evaluating early versus traditional oral feeding after colorectal surgery.Clinics (Sao Paulo, Brazil) · 2011Trial
- Prognostic value of carcinoembryonic antigen levels before and after curative surgery in colon cancer patients.Annals of surgical treatment and research · 2021Article
- Metastatic rectal cancer to papillary thyroid carcinoma: a case report and review of literature.BMC gastroenterology · 2020Review
- Early postoperative oral feeding shortens first time of bowel evacuation and prevents long term hospital stay in patients undergoing elective small intestine anastomosis.Gastroenterology and hepatology from bed to bench · 2019Article
- Evaluation of the Relationship between Carcinoembryonic Antigen and TNM Stage in Colorectal Cancer.The Eurasian journal of medicine · 2018Article
- Prospective study of neoadjuvant chemoradiotherapy using intensity-modulated radiotherapy and 5 fluorouracil for locally advanced rectal cancer - toxicities and response assessment.Cancer management and research · 2018Article
- Methods and novel technology for microRNA quantification in colorectal cancer screening.Clinical epigenetics · 2017Review
- The prognostic significance and treatment modality for elevated pre- and postoperative serum CEA in colorectal cancer patients.Annals of surgical treatment and research · 2016Article
- ERCC1 as a Predictive Marker for FOLFOX Chemotherapy in an Adjuvant Setting.Annals of coloproctology · 2015Article
- Preoperative carcinoembryonic antigen and prognosis of colorectal cancer. An independent prognostic factor still reliable.International surgery · 2015Article
- Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients.British journal of cancer · 2011Article
- Early Feeding after Colorectal Surgery in Children: Is it Safe?Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEvaluation of pre- and postoperative serum CEA levels together has seldom been assessed for the prognosis of colorectal cancer (CRC).
objectiveTo concurrently evaluate pre- and postoperative CEA as factors of relapse and survival.
methodsThe study consisted of 114 patients who had undergone surgery from February 2002 to June 2006 for CRC. All patients were classified into four groups according to their pre- and postoperative CEA levels. Data obtained for clinicopathologic parameters, lymph node metastasis, stage, recurrence, and CEA levels were analyzed to determine their association with survival. Multivariate analysis by the Cox proportional hazard regression model was performed to identify the independent prognostic factors associated with survival.
resultsPostoperative serum CEA levels remained high in Group 3 (n = 32). Nineteen patients (59.3%) demonstrated a detectable cause for persistent high CEA levels, while the reasons for those in the other thirteen patients (40.6%) remained obscure. Abnormal preoperative CEA levels significantly correlated with the depth of tumor invasion, lymph node metastasis, TNM stage, and recurrence (p < 0.05). Abnormal postoperative CEA levels were significantly related to the depth of tumor invasion, TNM stage, and postoperative relapse (p<0.05). Patients in Group 3 demonstrated the worst survival rate. Abnormal postoperative CEA levels, lymph node metastasis, and location of the tumor were independent prognostic factors for survival.
conclusionThe survival of patients with high postoperative CEA levels due to unknown reasons may be extended if they are exhaustively tested with sensitive diagnostic methods and treated at an early stage.
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