Evidence map›Paper›PMID 19488082›Full record

ReviewNature reviews. Neurology2009

Management of agitation and aggression associated with Alzheimer disease.

Clive G Ballard, Serge Gauthier, Jeffrey L Cummings, Henry Brodaty, George T Grossberg, Philippe Robert, Constantine G Lyketsos

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03662360 (Elderly Patients With Dementia in the Department of Acute Geriatrics), which is not on this map. Cited by 140 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03662360 nacompletednot on this mapstarted 2018, after this paper: background citation

Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior

TypeinterventionalSponsorClinica Luganese MoncuccoRan2018 to 2018Enrolled32ConditionsBPSD (Behavioral and Psycological Symptoms of Dementia)Armsessential oils
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Longitudinal course of behavioural and psychological symptoms of dementia: systematic review.The British journal of psychiatry : the journal of mental science · 2016
    Pooled it
  8. Effects of Person-Centered Care Approaches to Dementia Care on Staff: A Systematic Review.American journal of Alzheimer's disease and other dementias · 2015
    Pooled it
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  15. Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clive G BallardKing's College London, London, UK. clive.ballard@kcl.ac.uk
Serge Gauthier
Jeffrey L Cummings
Henry Brodaty
George T Grossberg
Philippe Robert
Constantine G Lyketsos

Funding

Alzheimer's Clinical Trial InnOvatioN (ACTION) InitiativeR35AG071476 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI CUMMINGS, JEFFREY L. · 2021 to 2025
$2.9M
NIA NIH HHS R35 AG071476
6 · The paper itself

Abstract

Agitation and aggression are frequently occurring and distressing behavioral and psychological symptoms of dementia (BPSD). These symptoms are disturbing for individuals with Alzheimer disease, commonly confer risk to the patient and others, and present a major management challenge for clinicians. The most widely prescribed pharmacological treatments for these symptoms-atypical antipsychotics-have a modest but significant beneficial effect in the short-term treatment (over 6-12 weeks) of aggression but limited benefits in longer term therapy. Benefits are less well established for other symptoms of agitation. In addition, concerns are growing over the potential for serious adverse outcomes with these treatments, including stroke and death. A detailed consideration of other pharmacological and nonpharmacological approaches to agitation and aggression in patients with Alzheimer disease is, therefore, imperative. This article reviews the increasing evidence in support of psychological interventions or alternative therapies (such as aromatherapy) as a first-line management strategy for agitation, as well as the potential pharmacological alternatives to atypical antipsychotics-preliminary evidence for memantine, carbamazepine, and citalopram is encouraging.

Indexed as

AggressionAlzheimer DiseaseAntipsychotic AgentsBehavior TherapyHumansPsychiatric Status Rating ScalesPsychomotor AgitationRandomized Controlled Trials as TopicAntipsychotic Agents

Identifiers

PMID19488082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.