ArticleProceedings of the National Academy of Sciences of the United States of America2009
Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
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- NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders.Pharmaceuticals (Basel, Switzerland) · 2024Review
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- The application and development of electron microscopy for three-dimensional reconstruction in life science: a review.Cell and tissue research · 2024Review
- A brain circuit and neuronal mechanism for decoding and adapting to change in daylength.bioRxiv : the preprint server for biology · 2023Article
- NO as a multimodal transmitter in the brain: discovery and current status.British journal of pharmacology · 2019Review
- From synaptically localized to volume transmission by nitric oxide.The Journal of physiology · 2016Review
- Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.Frontiers in neural circuits · 2016Article
- Polysialic Acid Acute Depletion Induces Structural Plasticity in Interneurons and Impairs the Excitation/Inhibition Balance in Medial Prefrontal Cortex Organotypic Cultures.Frontiers in cellular neuroscience · 2016Article
- Gestational and early postnatal hypothyroidism alters VGluT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats.Frontiers in neuroanatomy · 2015Article
- Three-dimensional spatial distribution of synapses in the neocortex: a dual-beam electron microscopy study.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Shift from phasic to tonic GABAergic transmission following laser-lesions in the rat visual cortex.Pflugers Archiv : European journal of physiology · 2013Article
- Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human.The Journal of comparative neurology · 2013Article
- Distribution of extrasynaptic NMDA receptors on neurons.TheScientificWorldJournal · 2012Review
- Espina: a tool for the automated segmentation and counting of synapses in large stacks of electron microscopy images.Frontiers in neuroanatomy · 2011Article
- Organization of NMDA receptors at extrasynaptic locations.Neuroscience · 2010Article
- Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.Frontiers in neuroanatomy · 2010Article
- Counting Synapses Using FIB/SEM Microscopy: A True Revolution for Ultrastructural Volume Reconstruction.Frontiers in neuroanatomy · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although pyramidal cells are the main excitatory neurons in the cerebral cortex, it has recently been reported that they can evoke inhibitory postsynaptic currents in neighboring pyramidal neurons. These inhibitory effects were proposed to be mediated by putative axo-axonic excitatory synapses between the axon terminals of pyramidal cells and perisomatic inhibitory axon terminals [Ren M, Yoshimura Y, Takada N, Horibe S, Komatsu Y (2007) Science 316:758-761]. However, the existence of this type of axo-axonic synapse was not found using serial section electron microscopy. Instead, we observed that inhibitory axon terminals synapsing on pyramidal cell bodies were frequently apposed by terminals that established excitatory synapses with neighbouring dendrites. We propose that a spillover of glutamate from these excitatory synapses can activate the adjacent inhibitory axo-somatic terminals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.